Ítem
Acceso Abierto

Molecular mimicry and autoimmunity in the time of COVID-19

Mostrar el registro sencillo de la publicación
dc.creatorRojas Quintana, Manuel Eduardo spa
dc.creatorHerrán, Maríaspa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorLeung, Patrick S.C.spa
dc.creatorAnaya, Juan Manuelspa
dc.creatorRidgway, William M.spa
dc.creatorGershwin, M. Ericspa
dc.date.accessioned2024-01-31T18:30:48Z
dc.date.available2024-01-31T18:30:48Z
dc.date.created2023-09-01spa
dc.date.issued2023spa
dc.descriptionInfectious diseases are commonly implicated as potential initiators of autoimmune diseases (ADs) and represent the most commonly known factor in the development of autoimmunity in susceptible individuals. Epidemiological data and animal studies on multiple ADs suggest that molecular mimicry is one of the likely mechanisms for the loss of peripheral tolerance and the development of clinical disease. Besides molecular mimicry, other mechanisms such as defects in central tolerance, nonspecific bystander activation, epitope-determinant spreading, and/or constant antigenic stimuli, may also contribute for breach of tolerance and to the development of ADs. Linear peptide homology is not the only mechanism by which molecular mimicry is established. Peptide modeling (i.e., 3D structure), molecular docking analyses, and affinity estimation for HLAs are emerging as critical strategies when studying the links of molecular mimicry in the development of autoimmunity. In the current pandemic, several reports have confirmed an influence of SARS-CoV-2 on subsequent autoimmunity. Bioinformatic and experimental evidence support the potential role of molecular mimicry. Peptide dimensional analysis requires more research and will be increasingly important for designing and distributing vaccines and better understanding the role of environmental factors related to autoimmunity.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttp://doi.org/10.1016/j.jaut.2023.103070spa
dc.identifier.issn0896-8411spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/42148
dc.language.isoengspa
dc.publisherUniversidad del Rosariospa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0896841123000793/pdfft?md5=f78313b86c394408920e04a947cf4556&pid=1-s2.0-S0896841123000793-main.pdfspa
dc.rightsAttribution 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/spa
dc.sourceJournal of Autoimmunityspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectAutoimmune diseasesspa
dc.subjectAutoimmunityspa
dc.subjectMolecular mimicryspa
dc.subjectCross-reactivityspa
dc.subjectVaccinesCOVID-19spa
dc.subjectSARS-CoV-2spa
dc.titleMolecular mimicry and autoimmunity in the time of COVID-19spa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Molecular_mimicry_autoimmunity_the_time_COVID-19.pdf
Tamaño:
2.54 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos