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Functionally relevant proteins in Plasmodium falciparum host cell invasion

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dc.creatorPatarroyo M.E.spa
dc.creatorAlba M.P.spa
dc.creatorRojas-Luna R.spa
dc.creatorBermudez A.spa
dc.creatorAza-Conde J.spa
dc.date.accessioned2020-05-26T00:11:11Z
dc.date.available2020-05-26T00:11:11Z
dc.date.created2017spa
dc.description.abstractA totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins involved in critical biological functions for parasite survival and highlights the conserved amino acid sequences of the most important proteins involved in sporozoite invasion of hepatocytes and merozoite invasion of red blood cells. Conserved high activity binding peptides are located in such proteins' functionally strategic sites, whose functions are related to receptor binding, nutrient and protein transport, enzyme activity and molecule-molecule interactions. They are thus excellent targets for vaccine development as they block proteins binding function involved in invasion and also their biological function. © 2017 Future Medicine Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2217/imt-2016-0091
dc.identifier.issn1750743X
dc.identifier.issn17507448
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24286
dc.language.isoengspa
dc.publisherFuture Medicine Ltd.spa
dc.relation.citationEndPage155
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage131
dc.relation.citationTitleImmunotherapy
dc.relation.citationVolumeVol. 9
dc.relation.ispartofImmunotherapy, ISSN:1750743X, 17507448, Vol.9, No.2 (2017); pp. 131-155spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85011074067&doi=10.2217%2fimt-2016-0091&partnerID=40&md5=bce0864b96e735705dfa8365de4caf07spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordApical membrane antigen 1spa
dc.subject.keywordfalciparumeng
dc.subject.keywordCircumsporozoite protein 1spa
dc.subject.keywordErythrocyte binding antigen 140spa
dc.subject.keywordErythrocyte binding antigen 181spa
dc.subject.keywordErythrocyte binding antigen 75spa
dc.subject.keywordErythrocyte binding ligandspa
dc.subject.keywordErythrocyte binding ligand 1spa
dc.subject.keywordLiver stage antigen 1spa
dc.subject.keywordLiver stage antigen 3spa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordMerozoite apical erythrocyte binding ligandspa
dc.subject.keywordMerozoite surface protein 1spa
dc.subject.keywordMerozoite surface protein 10spa
dc.subject.keywordMerozoite surface protein 2spa
dc.subject.keywordMerozoite surface protein 4spa
dc.subject.keywordMerozoite surface protein 7spa
dc.subject.keywordMerozoite surface protein 9spa
dc.subject.keywordMultidomain sporozoite surface protein 2spa
dc.subject.keywordParasite antigenspa
dc.subject.keywordSerine repeat antigen 5spa
dc.subject.keywordSporozoite invasion associated protein 1spa
dc.subject.keywordSporozoite invasion associated protein 2spa
dc.subject.keywordSporozoite microneme protein essential for cell transversal 1spa
dc.subject.keywordSporozoite microneme protein essential for cell transversal 2spa
dc.subject.keywordSporozoite proteinspa
dc.subject.keywordSporozoite threonine and asparagine rich proteinspa
dc.subject.keywordThrombospondin related anonymous proteinspa
dc.subject.keywordThrombospondin related sporozoite proteinspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordUnindexed drugspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordCell invasionspa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordDrug safetyspa
dc.subject.keywordErythrocytespa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordLiver cellspa
dc.subject.keywordMalariaspa
dc.subject.keywordMerozoitespa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasite immunityspa
dc.subject.keywordParasite survivalspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtein secondary structurespa
dc.subject.keywordProtein structurespa
dc.subject.keywordProtein tertiary structurespa
dc.subject.keywordReviewspa
dc.subject.keywordSporozoitespa
dc.subject.keywordVaccinationspa
dc.subject.keywordAnimalspa
dc.subject.keywordDrug designspa
dc.subject.keywordHost pathogen interactionspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMalaria falciparumspa
dc.subject.keywordMetabolismspa
dc.subject.keywordNuclear magnetic resonance spectroscopyspa
dc.subject.keywordParasitologyspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordX ray crystallographyspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordCrystallographyeng
dc.subject.keywordDrug designspa
dc.subject.keywordErythrocytesspa
dc.subject.keywordHepatocytesspa
dc.subject.keywordHost-pathogen interactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordMagnetic resonance spectroscopyspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMalariaeng
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordChabpspa
dc.subject.keywordInvasion-proteinsspa
dc.subject.keywordMalariaspa
dc.subject.keywordMerozoitespa
dc.subject.keywordSporozoitespa
dc.subject.keywordVaccinespa
dc.titleFunctionally relevant proteins in Plasmodium falciparum host cell invasionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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