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Serum levels of secretory IgA and in vitro production of IgA in rheumatoid arthritis

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorJorgensen, C.spa
dc.creatorGutierrez, M.spa
dc.creatorReme, T.spa
dc.creatorSany, J.spa
dc.date.accessioned2020-08-19T14:40:34Z
dc.date.available2020-08-19T14:40:34Z
dc.date.created1993spa
dc.description.abstractTwenty-three per cent of rheumatoid arthritis (RA) patients show an increase of serum IgA concentrations. To determine the role of mucous-associated lymphoid tissue (MALT) in the elevation of serum IgA in RA, we studied the serum secretory-IgA (s-IgA) in 63 RA patients and in 30 healthy controls. We also analysed the secretion of circulating B cells producing IgA, which is known to reflect mucous tissue activity, in a subgroup of 15 patients with increased serum IgA concentrations, and in control patients. The mean s-IgA in the RA patients was 0.046 mg/ml +/- 0.064, versus 0.002 +/- 0.004 mg/ml in controls (not significant). Active disease defined by clinical criteria was associated with an increase in serum s-IgA (p < 0.001). Furthermore, in a subgroup of RA patients with high serum IgA levels, we found an increase in in vitro IgA production by circulating blood lymphocytes (17.39 +/- 15.2 micrograms/ml), versus RA patients with normal serum IgA levels or controls (p < 0.001). These results were not modified by LPS or PWM. Our results further support the hypothesis of primary MALT activation following environmental antigenic stimulation in RA patients.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN: 0392-856X
dc.identifier.issnEISSN: 1593-098X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26938
dc.language.isoengspa
dc.publisherEurope PMCspa
dc.relation.citationEndPage544
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage541
dc.relation.citationTitleClinical and Experimental Rheumatology
dc.relation.citationVolumeVol. 11
dc.relation.ispartofClinical and Experimental Rheumatology, ISSN: 0392-856X; EISSN: 1593-098X, Vol.11, No.5 ( 31 Aug 1993); pp. 541-544spa
dc.relation.urihttps://europepmc.org/article/med/8275590spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceClinical and Experimental Rheumatologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSerum IgA concentrationsspa
dc.titleSerum levels of secretory IgA and in vitro production of IgA in rheumatoid arthritisspa
dc.title.TranslatedTitleNiveles séricos de IgA secretora y producción in vitro de IgA en la artritis reumatoideeng
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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