Ítem
Acceso Abierto

Índices neutrófilos/linfocitos y plaquetas/linfocitos como predictores de preeclampsia en la Clínica Universitaria Colombia

Mostrar el registro sencillo de la publicación
dc.contributor.advisorRodríguez, Olga Yolima
dc.contributor.advisorHerrera Mendez, Emiliano Mauricio
dc.contributor.advisorIbáñez Pinilla, Milcíades
dc.creatorCampo Elíaz, Jorge Luís
dc.creatorRangel Ramos, Víctor Saúl
dc.creator.degreeEspecialista en Ginecología y Obstericia
dc.date.accessioned2018-07-19T16:56:26Z
dc.date.available2018-07-19T16:56:26Z
dc.date.created2018-07-09
dc.date.issued2018
dc.descriptionIntroducción: La preeclampsia afecta del 5 al 8% de los embarazos y se considera la segunda causa de muerte materna a nivel mundial, alcanzando un 10-15% de los casos. Recientemente, algunos autores proponen la utilización de los índices neutrófilo/linfocito (INL) y plaqueta/linfocito (IPL) como marcadores pronósticos de preeclampsia. Determinar la utilidad de estos índices en nuestro país podría ayudar a la identificación oportuna de las pacientes en riesgo, especialmente en sitios con recursos limitados y difícil acceso a los servicios de salud. Materiales y métodos: Se realizó un estudio de predicción donde se seleccionaron de las pacientes que consultaron a la Clínica Universitaria Colombia en el periodo transcurrido entre el 2015-2017 conformando dos grupos de análisis. Se calcularon los Índice neutrófilos/linfocitos y plaquetas/linfocitos a partir de los hemogramas realizados en el primer trimestre del embarazo y se analizó su asociación con la aparición de preeclampsia con o sin criterios de severidad, calculando las características operativas de la prueba. Resultados: Al realizar la comparación de los índices neutrófilos/linfocitos y plaquetas/linfocitos para determinar relación con preeclampsia, entre los dos grupos no se encontraron diferencias significativas entre las medianas de INL (p=0.368, Test de Mann Whitney), ni en IPL (p=0.608, Test de Mann Whitney). La capacidad de predicción de preeclampsia severa que se encontró con el INL, mostro un área de predicción no significativa del 50.9% para preeclampsia (p= 0,819, IC 95%: 43.4-58.4%) y el IPL un área de predicción no significativa de 54.6% para preeclampsia severa (p=0,235, IC 95%: 47,2 – 62.0%).spa
dc.description.abstractIntroduction: Preeclampsia affects 5 to 8% of pregnancies and is considered the second cause of maternal death worldwide, reaching 10-15% of cases. Recently, some authors propose the use of neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios as prognostic markers of preeclampsia. Determining the usefulness of these indices in our country could help the timely identification of patients at risk, especially in places with limited resources and difficult access to health services. Materials and methods: A prediction study was carried out where the patients who consulted the University Clinic Colombia in the period between 2015-2017 were selected, forming two groups of analysis. The neutrophil/lymphocyte and platelet/lymphocyte ratios were calculated from the haemograms performed in the first trimester of pregnancy and their association with the occurrence of preeclampsia with or without criteria of severity was analyzed, calculating the operational characteristics of the test. Results: When comparing the neutrophil/lymphocyte and platelet/lymphocyte ratios to determine relationship with preeclampsia, between the two groups no significant differences were found between the NLR medians (p = 0.368, Mann Whitney test), nor in PLR (p = 0.608, Mann Whitney Test). The predictive capacity of severe preeclampsia that was found with the NLR, showed a non-significant predictive area of 50.9% for preeclampsia (p = 0.819, 95% CI: 43.4-58.4%) and the PLR a non-significant predictive area of 54.6% for severe preeclampsia (p = 0.235, 95% CI: 47.2 - 62.0%).eng
dc.description.embargo2019-08-01 06:01:01: Script de automatizacion de embargos. info:eu-repo/date/embargoEnd/2019-07-19spa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_18209
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18209
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Ginecología y Obstericiaspa
dc.rightsAtribución-NoComercial 2.5 Colombiaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.5/co/
dc.source.bibliographicCitation1. Hypertension in Pregnancy. Obstetrics & Gynecology. 2013;122(5):1122-1131.
dc.source.bibliographicCitation2. Turner J. Diagnosis and management of pre-eclampsia: an update. International Journal of Women's Health. 2010;327.
dc.source.bibliographicCitation3. Duley L. The Global Impact of Pre-eclampsia and Eclampsia. Seminars in Perinatology. 2009;33(3):130-137.
dc.source.bibliographicCitation4. Departamento Administrativo Nacional de Estadística DANE [www. dane.gov.co]. Bogotá: DANE; c2015 [actualizada 16 febrero 2015; consultado 22 junio de 2017]. Disponible en: http://dane.gov.co/
dc.source.bibliographicCitation5. Cortés-yepes H. Doppler de arterias uterinas en el primer trimestre del embarazo para la detección de los trastornos hipertensivos asociados con el embarazo: estudio de cohorte. Bogotá (Colombia) 2007-2008. Revista Colombiana de Obstetricia y Ginecología, 2009; 60(4): 328-333
dc.source.bibliographicCitation6. Anderson UD, Gram M, Akerstrom B, Hansson SR. First trimester prediction of preeclampsia. Current hypertension reports. 2015;17(9):584.
dc.source.bibliographicCitation7. Kurtoglu E, Kokcu A, Celik H, Tosun M, Malatyalioglu E. May ratio of neutrophil to lymphocyte be useful in predicting the risk of developing preeclampsia? A pilot study. The Journal of Maternal-Fetal & Neonatal Medicine. 2014Sep;28(1):97–9
dc.source.bibliographicCitation8. Toptas M, Asik H, Kalyoncuoglu M, Can E, Can MM. Are Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio Predictors for Severity of Preeclampsia? Journal of Clinical Gynecology and Obstetrics. 2016;5(1):27–31.
dc.source.bibliographicCitation9. Kirbas A. Prediction of Preeclampsia By First Trimester Combined Test and Simple Complete Blood Count Parameters. Journal Of Clinical And Diagnostic Research. 2015Nov;9(11):QC20-3
dc.source.bibliographicCitation10. Prasmusinto D, Jono RC, Lisnawati Y. Neutrophil Lymphocyte Ratio and Red Cell Distribution Width as a Marker of Preeclampsia: A Retrospective Study. Journal of Pregnancy and Child Health. 2017;04(02):29-32.
dc.source.bibliographicCitation11. Ministerio de Salud y Protección Social 2016. Análisis de situación de salud (ASIS) Colombia. Bogotá. Dirección de epidemiología y demografía. Ministerio de Salud y Protección Social. 56-59
dc.source.bibliographicCitation12. El tiempo. Colombia tiene una enorme brecha de mortalidad materna entre regiones. 23 junio de 2015
dc.source.bibliographicCitation13. Velauthar L, Plana M, Kalidindi M, Zamora J, Thilaganathan B, Illanes S et al. First-trimester uterine artery Doppler and adverse pregnancy outcome: a meta-analysis involving 55 974 women. Ultrasound in Obstetrics & Gynecology. 2014;43(5):500-507.
dc.source.bibliographicCitation14. Gupte S, Wagh G. Preeclampsia–Eclampsia. The Journal of Obstetrics and Gynecology of India. 2014;64(1):4-13.
dc.source.bibliographicCitation15. Burton G, Jauniaux E. Placental Oxidative Stress: From Miscarriage to Preeclampsia. Journal of the Society for Gynecologic Investigation. 2004;11(6):342-352.
dc.source.bibliographicCitation16. Rovere-Querini P, Castiglioni M, Sabbadini M, Manfredi A. Signals of cell death and tissue turnover during physiological pregnancy, pre-eclampsia, and autoimmunity. Autoimmunity. 2007;40(4):290-294.
dc.source.bibliographicCitation17. Messerli M, May K, Hansson S, Schneider H, Holzgreve W, Hahn S et al. Feto-maternal interactions in pregnancies: Placental microparticles activate peripheral blood monocytes. Placenta. 2010;31(2):106-112.
dc.source.bibliographicCitation18. LaMarca B, (2010). The role of immune activation in contributing to vascular dysfunction and the pathophysiology of hypertension during preeclampsia. Minerva Ginecologica. 2010;62(2):105–120.
dc.source.bibliographicCitation19. Leik C, Walsh S. Neutrophils Infiltrate Resistance-Sized Vessels of Subcutaneous Fat in Women With Preeclampsia. Hypertension. 2004;44(1):72-77.
dc.source.bibliographicCitation20. Sasaki Y, Darmochwal-Kolarz D, Suzuki D, Sakai M, Ito M, Shima T et al. Proportion of peripheral blood and decidual CD4+ CD25bright regulatory T cells in pre-eclampsia. Clinical & Experimental Immunology. 2007;149(1):139-145.
dc.source.bibliographicCitation21. Zusterzeel P, Wanten G, Peters W, Merkus H, Steegers E. Neutrophil oxygen radical production in pre-eclampsia with HELLP syndrome. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2001;99(2):213-218.
dc.source.bibliographicCitation22. Tsukimori K, Fukushima K, Tsushima A, Nakano H. Generation of Reactive Oxygen Species by Neutrophils and Endothelial Cell Injury in Normal and Preeclamptic Pregnancies. Hypertension. 2005;46(4):696-700.
dc.source.bibliographicCitation23. Shah T, Walsh S. Activation of NF-κB and expression of COX-2 in association with neutrophil infiltration in systemic vascular tissue of women with preeclampsia. American Journal of Obstetrics and Gynecology. 2007;196(1):48.e1-48.e8.
dc.source.bibliographicCitation24. Bachawaty T, Washington S, Walsh S. Neutrophil Expression of Cyclooxygenase 2 in Preeclampsia. Reproductive Sciences. 2010;17(5):465-470.
dc.source.bibliographicCitation25. Laresgoiti-Servitje E. A leading role for the immune system in the pathophysiology of preeclampsia. Journal of Leukocyte Biology. 2013;94(2):247-257.
dc.source.bibliographicCitation26. Gervasi M, Chaiworapongsa T, Pacora P, Naccasha N, Yoon B, Maymon E et al. Phenotypic and metabolic characteristics of monocytes and granulocytes in preeclampsia. American Journal of Obstetrics and Gynecology. 2001;185(4):792-797.
dc.source.bibliographicCitation27. Kraayenbrink AA, Dekker GA, Van Kamp GJ, Van Geijn HP. Endothelial vasoactive mediators in preeclampsia. Am J Obstet Gynecol. 1993;169(1):160-165.
dc.source.bibliographicCitation28. Livingston J, Maxwell B. “Preeclampsia: Theories and speculations”. Wiener KlinischeWochenschrift. 2003;115(5-6):145-148.
dc.source.bibliographicCitation29. Tubbergen P, Lachmeijer A, Althuisius S, Vlak M, Van Geijn H, Dekker G. Change in paternity: A risk factor for preeclampsia in multiparous women? J Reprod Immunol. 1999;45(1):81-88.
dc.source.bibliographicCitation30. Perry K, Martin J. Abnormal hemostasis and coagulopathy in preeclampsia and eclampsia. Clin Obstet Gynecol. 1992;35(2):338-350.
dc.source.bibliographicCitation31. Mastrogiannis D, O’Brien W, Krammer J, Benoit R. Potential role of endothelin-1 in normal and hypertensive pregnancies. Am J Obstet Gynecol. 1991;165(6-1):1711-1716.
dc.source.bibliographicCitation32. Casmod Y, Van Dyk B, Nicolaou E. Uterine artery Doppler screening as a predictor of pre-eclampsia. Health SA Gesondheid. 2016;21:391-396.
dc.source.bibliographicCitation33. Ghidini A, Locatelli A. Monitoring of Fetal Well-Being: Role of Uterine Artery Doppler. Seminars in Perinatology. 2008;32(4):258-262.
dc.source.bibliographicCitation34. Martin AM, Bindra R, Curcio P, Cicero S, Nicolaides KH, et al. Screening for preeclampsia and fetal growthrestriction by uterine artery Doppler at 11 – 14 weeks of gestation. Ultrasound ObstetGynecol2001;18:583-6.
dc.source.bibliographicCitation35. Gómez O, Martínez JM, Figueras F, Del Río M,Borobio V, Puerto B, et al. Uterine artery Doppler at 11 – 14 weeks of gestation to screen for hypertensive disorders and associated complications in an unselected population. Ultrasound ObstetGynecol2005;26:490-4.
dc.source.bibliographicCitation36. Figueras F, Puerto B. Guia Clínica: Doppler en Medicina Fetal. Guías clínicas medicina fetal y perinatal. Servicio de medicina fetal Hospital Clínic Barcelona. 2014.
dc.source.bibliographicCitation37. Khong S, Kane S, Brennecke S, da Silva Costa F. First-Trimester Uterine Artery Doppler Analysis in the Prediction of Later Pregnancy Complications. Disease Markers. 2015;2015:1-10
dc.source.bibliographicCitation38. Conde-Agudelo A, Villar J, Lindheimer M. World Health Organization systematic review of screening tests for preeclampsia. Obstet Gynecol. 2004;104(6):1367–91.
dc.source.bibliographicCitation39. Zahorec R. Ratio of neutrophil to lymphocyte counts: rapid and simple parameter of systemic inflammation and stress in critically ill. BratislLekListy. 2001(1);102:5–14
dc.source.bibliographicCitation40. Szkandera J, Stotz M, Eisner F, Absenger G, Stojakovic T, Samonigg H, et al. External Validation of the Derived Neutrophil to Lymphocyte Ratio as a Prognostic Marker on a Large Cohort of Pancreatic Cancer Patients. PLoS ONE. 2013;8(11):e78225.
dc.source.bibliographicCitation41. Huang Q-T, Zhou L, Zeng W-J, Ma Q-Q, Wang W, Zhong M, et al. Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis of Observational Studies. Cellular Physiology and Biochemistry. 2017;41(6):2411-8.
dc.source.bibliographicCitation42. Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A. Are Neutrophil/Lymphocyte and Platelet/Lymphocyte Rates in Patients with Non-Small Cell Lung Cancer Associated with Treatment Response and Prognosis? Asian Pacific Journal of Cancer Prevention. 2013;14(9):5237–42
dc.source.bibliographicCitation43. Cho, H., Hur, H.W., Kim, S.W. et al. Pre-treatment neutrophil to lymphocyte ratio is elevated
in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother. 2009;58(1):15-23
dc.source.bibliographicCitation44. Tamhane UU, Aneja S, Montgomery D, Rogers E-K, Eagle KA, Gurm HS. Association Between Admission Neutrophil to Lymphocyte Ratio and Outcomes in Patients With Acute Coronary Syndrome. The American Journal of Cardiology. 2008;102(6):653–7.
dc.source.bibliographicCitation45. Núñez J, Núñez E, Bodí V, Sanchis J, Miñana G, Mainar L, et al. Usefulness of the Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality in ST Segment Elevation Myocardial Infarction. The American Journal of Cardiology. 2008;101(6):747–52.
dc.source.bibliographicCitation46. Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an Elevated Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality After Percutaneous Coronary Intervention. The American Journal of Cardiology. 2006;97(7):993–6.
dc.source.bibliographicCitation47. Karaman M, Balta Ş, Ay S, Cakar M, Naharci I, Demirkol S, et al. Op-106 The Comparative Effects Of Valsartan And Amlodipine On Vwf Levels And N/l Ratio In Patients With Newly Diagnosed Hypertension. Clin Exp Hypertens. 2013;35(7):516-22
dc.source.bibliographicCitation48. Expert Panel On Detection, Evaluation, And Treatment Of High Blood Cholesterol In Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA: The Journal of the American Medical Association. 2001;285(19):2486–97.
dc.source.bibliographicCitation49. Lou M, Luo P, Tang R, Peng Y, Yu S, Huang W, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC EndocrDisord. 2015 Mar 2;15:9.
dc.source.bibliographicCitation50. Kuyumcu ME, Yesil Y, Oztürk ZA, Kizilarslanoğlu C, Etgül S, Halil M, Ulger Z, Cankurtaran M, Arıoğul S, The Evaluation of Neutrophil-Lymphocyte Ratio in Alzheimer’s Disease. Dement GeriatrCognDisord. 2012;34(2):69-74
dc.source.bibliographicCitation51. Raungkaewmanee S, Tangjitgamol S, Manusirivithaya S, Srijaipracharoen S, Thavaramara T. Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer. Journal of Gynecologic Oncology. 2012;23(4):265.
dc.source.bibliographicCitation52. Akıl M. Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity. Kosuyolu Heart Journal. 2015;18(2):84-88.
dc.source.bibliographicCitation53. Serin S, Avcı F, Ercan O, Köstü B, Bakacak M, Kıran H. Is neutrophil/lymphocyte ratio a useful marker to predict the severity of pre-eclampsia? Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health. 2016;6(1):22–5.
dc.source.bibliographicCitation54. Yücel B, Ustun B. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, red cell distribution width and plateletcrit in preeclampsia. Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health. 2017;7:29–32
dc.source.bibliographicCitation55. Hotchkiss R, Karl I. The Pathophysiology and Treatment of Sepsis. New England Journal of Medicine. 2003;348(2):138-150.
dc.source.bibliographicCitation56. Villasmil E, Pérez C, Bolívar J. Invasión trofoblástica en el embarazo normal (II): Placentación profunda [Internet]. Dialnet.unirioja.es. 2018 [cited 21 May 2018]. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=4796916
dc.source.bibliographicCitation57. Roberge S, Bujold E, Nicolaides K. Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis. American Journal of Obstetrics and Gynecology. 2018;218(3):287-293.e1.
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectPreeclampsiaspa
dc.subjectPredicciónspa
dc.subjectÍndice Neutrófilo/Linfocitospa
dc.subjectÍndice Plaqueta/Linfocitospa
dc.subject.ddcGinecología & otras especialidades médicas
dc.subject.keywordPreeclampsiaeng
dc.subject.keywordPredictioneng
dc.subject.keywordNeutrophil/Lymphocyte Ratioeng
dc.subject.keywordPlatelet/Lymphocyte Ratioeng
dc.subject.lembPreeclampsiaspa
dc.subject.lembComplicaciones del embarazospa
dc.titleÍndices neutrófilos/linfocitos y plaquetas/linfocitos como predictores de preeclampsia en la Clínica Universitaria Colombiaspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
INDICES-NEUTROFILOSLINFOCITOS-Y-PLAQUETASLINFOCITOS-COMO-PREDICTORES-DE-PREECLAMPSIA-(1).pdf
Tamaño:
1.45 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Especialización en Ginecología y Obstetricia