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Differential regulation of AKT, MAPK and GSK3? during C2-ceramide-induced neuronal death

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dc.creatorArboleda, Gonzalospa
dc.creatorCárdenas, Yolandaspa
dc.creatorRodríguez, Yeldyspa
dc.creatorMorales, Luis Carlosspa
dc.creatorMatheus Merino, Luisa Marinaspa
dc.creatorArboleda, Humbertospa
dc.date.accessioned2020-05-25T23:57:24Z
dc.date.available2020-05-25T23:57:24Z
dc.date.created2010spa
dc.description.abstractEvidence has implicated apoptosis as a mechanism underlying cell demise in diverse neurodegenerative diseases including Parkinson's disease (PD). Endogenous toxins and other stress signals activate the sphingomyelin pathway increasing the levels of ceramide, an important regulator of cell death.In the present paper we have analysed the contribution of PI3K/AKT-GSK3? and MAPK (ERK and JNK) pathways to cell death in a catecholaminergic cell line following exposure to C2-ceramide. We also explored the potential neuroprotective action of insulin-like growth factor-1 (IGF-1) and neurotrophin-3 (NT3).We demonstrated that C2-ceramide-induced cell death is associated to an early decrease in phosphorylation (inhibition) of PI3K/AKT and ERK, followed by phosphorylation (activation) of JNK and de-phosphorylation (activation) of glycogen synthase kinase-3 beta (GSK3?). NT3 and IGF-1 increased survival at early time points, but only IGF-1 is capable to attenuate C2-ceramide-mediated neuronal death, and this neuroprotection is associated to strong and permanent activation of AKT and inhibition of GSK3?. In conclusion, C2-ceramide initiates a series of events including an early inactivation of PI3K/AKT and ERK pathways followed by activation of JNK and activation of GSK3? and neuronal death, changes that are counteracted by IGF-1. © 2010 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.neuro.2010.08.001
dc.identifier.issn0161813X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22659
dc.language.isoengspa
dc.relation.citationEndPage693
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage687
dc.relation.citationTitleNeuroToxicology
dc.relation.citationVolumeVol. 31
dc.relation.ispartofNeuroToxicology, ISSN:0161813X, Vol.31, No.6 (2010); pp. 687-693spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-78049457564&doi=10.1016%2fj.neuro.2010.08.001&partnerID=40&md5=d4bcf42614706c0b4c393d4024609e5espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCeramidespa
dc.subject.keywordGlycogen synthase kinase 3betaspa
dc.subject.keywordMitogen activated protein kinasespa
dc.subject.keywordNeurotrophin 3spa
dc.subject.keywordProtein kinase bspa
dc.subject.keywordSomatomedin cspa
dc.subject.keywordArticlespa
dc.subject.keywordCell culturespa
dc.subject.keywordCell linespa
dc.subject.keywordCell survivalspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDrug exposurespa
dc.subject.keywordEnzyme activationspa
dc.subject.keywordEnzyme inhibitionspa
dc.subject.keywordEnzyme phosphorylationspa
dc.subject.keywordEnzyme regulationspa
dc.subject.keywordNerve cell necrosisspa
dc.subject.keywordNeuroprotectionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordAnimalsspa
dc.subject.keywordCell deathspa
dc.subject.keywordCell survivalspa
dc.subject.keywordGlycogen synthase kinase 3spa
dc.subject.keywordInsulin-like growth factor ispa
dc.subject.keywordMicespa
dc.subject.keywordMitogen-activated protein kinasesspa
dc.subject.keywordNeuronsspa
dc.subject.keywordNeuroprotective agentsspa
dc.subject.keywordProto-oncogene proteins c-aktspa
dc.subject.keywordSphingosinespa
dc.subject.keywordAktspa
dc.subject.keywordApoptosisspa
dc.subject.keywordCad cellsspa
dc.subject.keywordCeramidespa
dc.subject.keywordGsk3?spa
dc.subject.keywordIgf-1spa
dc.subject.keywordMapkspa
dc.titleDifferential regulation of AKT, MAPK and GSK3? during C2-ceramide-induced neuronal deathspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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