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Cardiovascular involvement in autoimmune diseases

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dc.creatorAmaya-Amaya, Jenny
dc.creatorMontoya-Sánchez, Laura
dc.creatorRojas-Villarraga, Adriana
dc.creator.googleAmaya-Amaya, Jennyspa
dc.creator.googleMontoya-Sánchez, Lauraspa
dc.creator.googleRojas-Villarraga, Aadrianaspa
dc.date.accessioned2020-04-27T13:02:49Z
dc.date.available2020-04-27T13:02:49Z
dc.date.created2014
dc.date.issued2014
dc.description.abstractAutoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiological abnormalities, and certain subphenotypes. Atherosclerosis (AT) was once considered to be a degenerative disease that was an inevitable consequence of aging. However, research in the last three decades has shown that AT is not degenerative or inevitable. It is an autoimmune-inflammatory disease associated with infectious and inflammatory factors characterized by lipoprotein metabolism alteration that leads to immune system activation with the consequent proliferation of smooth muscle cells, narrowing arteries, and atheroma formation. Both humoral and cellular immune mechanisms have been proposed to participate in the onset and progression of AT. Several risk factors, known as classic risk factors, have been described. Interestingly, the excessive cardiovascular events observed in patients with ADs are not fully explained by these factors. Several novel risk factors contribute to the development of premature vascular damage. In this review, we discuss our current understanding of how traditional and nontraditional risk factors contribute to pathogenesis of CVD in AD. © 2014 Jenny Amaya-Amaya et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2014/367359
dc.identifier.issn2314-6133
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21773
dc.language.isoengspa
dc.relation.citationTitleBioMed Research International
dc.relation.citationVolumeVol. 2014
dc.relation.ispartofBioMed Research International, ISSN: 2314-6133 Vol. 2014, (2014)spa
dc.relation.urihttps://www.hindawi.com/journals/bmri/2014/367359/spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcEnfermedadesspa
dc.subject.keywordAutoimmune Diseasesspa
dc.subject.keywordSystemiceng
dc.subject.keywordCausalityspa
dc.subject.keywordComorbidityspa
dc.subject.keywordHumansspa
dc.subject.keywordIncidencespa
dc.subject.keywordRheumatic Diseasesspa
dc.subject.keywordRisk Factorsspa
dc.subject.keywordSclerodermaeng
dc.titleCardiovascular involvement in autoimmune diseasesspa
dc.typerevieweng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaRevisiónspa
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