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Geographical Differences in Autoantibodies and Anti-infectious Agents Antibodies Among Healthy Adults

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dc.creatorShapira, Yinonspa
dc.creatorPoratKatz, Bat-Shevaspa
dc.creatorGilburd, Borisspa
dc.creatorBarzilai, Orispa
dc.creatorRam, Mayaspa
dc.creatorBlank, Mirispa
dc.creatorLindeberg, Staffanspa
dc.creatorFrostegård, Johanspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorBizzaro, Nicolaspa
dc.creatorJara, Luis J.spa
dc.creatorDamoiseaux, Janspa
dc.creatorShoenfeld, Yehudaspa
dc.creatorAgmon Levin, Nancyspa
dc.date.accessioned2020-08-06T16:21:33Z
dc.date.available2020-08-06T16:21:33Z
dc.date.created2011-01-13spa
dc.description.abstractMuch is known about the geoepidemiology of defined autoimmune diseases (AD); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. The aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodies in those regions. Sera samples from 557 healthy donors were obtained at six centers located in different countries (i.e., Italy, Netherlands, Israel, Mexico, Columbia, Papua New Guinea (Kitavans)). Sera were tested for the presence of antinuclear antibodies (ANA) and autoantibodies associated with thrombophilia, vasculitis, and gastrointestinal (GI) disease. Sera samples were also screened for antibodies against infectious agents (i.e., EBV, CMV, HBV, Helicobacter pylori, Treponema pallidum, and Toxoplasma gondii). Tests were performed using the BioPlex 2200 or ELISA kits (Bio-Rad Laboratories, USA). We found a significant gradient of ANA positivity among the groups: 45% of Columbians, 38% of Kitavans, 26% of Mexicans, 12% of Italians, 12% of Dutch, and 11% of Israelis were ANA positive. Geographical differences were also observed regarding the prevalence of specific autoantibodies, namely ANA: anti-dsDNA, chromatin, SmRNP, Ro/SSA, La/SSB, Scl70; GI associated: antigliadin; and thrombophilia-associated: anti-?2GP1 and prothrombin. Additionally, significant differences were observed regarding serological markers of all infectious agents screened. The observed variance between healthy ethno-geographical distinct populations in prevalence of autoantibodies may represent different genetic or environmental (e.g., prior exposure to infection) influences. Thus may illuminate possible causes of geoepidemiological differences in AD.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s12016-010-8241-z
dc.identifier.issnISSN: 1080-0549
dc.identifier.issnEISSN: 1559-0267
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26394
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage163
dc.relation.citationStartPage154
dc.relation.citationTitleClinical Reviews in Allergy & Immunology
dc.relation.citationVolumeVol. 42
dc.relation.ispartofClinical Reviews in Allergy & Immunology, ISSN: 1080-0549 ; EISSN: 1559-0267, Vol.42 (2012-04); pp.154-163spa
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs12016-010-8241-zspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceClinical Reviews in Allergy & Immunologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAutoimmune Diseasesspa
dc.subject.keywordColombiaspa
dc.subject.keywordCross-Sectional Studiesspa
dc.subject.keywordEthnic Groupsspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordIsraelspa
dc.subject.keywordItalyspa
dc.subject.keywordMalespa
dc.subject.keywordMexicospa
dc.subject.keywordNetherlandsspa
dc.subject.keywordPapua New Guineaspa
dc.subject.keywordPrevalencespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGeoepidemiologyspa
dc.subject.keywordEthnicityspa
dc.subject.keywordAntinuclear antibodiesspa
dc.subject.keywordAntigliadinspa
dc.subject.keywordAntiphospholipid antibodiesspa
dc.subject.keywordInfectious agentsspa
dc.titleGeographical Differences in Autoantibodies and Anti-infectious Agents Antibodies Among Healthy Adultsspa
dc.title.TranslatedTitleDiferencias geográficas en autoanticuerpos y anticuerpos contra agentes infecciosos entre adultos sanosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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