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Chlamydia trachomatis frequency in a cohort of HPV-infected colombian women

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dc.creatorQuinónez-Calvache, Edith Margarita
dc.creatorRios-Chaparro, Dora-Ines
dc.creatorRamírez, Juan David
dc.creatorSoto-De León, Sara Cecilia
dc.creatorCamargo, Milena
dc.creatorDel Río-Ospina, Luisa
dc.creatorSánchez, Ricardo
dc.creatorPatarroyo, Manuel Elkin
dc.creatorPatarroyo, Manuel A.
dc.creator.googleQuinónez-Calvache, Edith Margaritaspa
dc.creator.googleRios-Chaparro, Dora-Inesspa
dc.creator.googleRamírez, Juan Davidspa
dc.creator.googleSoto-De León, Sara Ceciliaspa
dc.creator.googleCamargo, Milenaspa
dc.creator.googleSánchez, Ricardospa
dc.creator.googlePatarroyo, Manuel Elkinspa
dc.creator.googlePatarroyo, Manuel Alfonsospa
dc.date.accessioned2019-01-28T20:02:13Z
dc.date.available2019-01-28T20:02:13Z
dc.date.created2016
dc.date.issued2016-01-25
dc.description.abstractBackground Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium, is the commonest infectious bacterial agent of sexual transmission throughout the world. It has been shown that the presence of this bacteria in the cervix represents a risk regarding HPV persistence and, thereafter, in developing cervical cancer (CC). Prevalence rates may vary from 2% to 17% in asymptomatic females, depending on the population being analysed. This study reports the identification of C. trachomatis in a cohort of 219 HPV-infected Colombian females. Methods C. trachomatis infection frequency was determined during each of the study’s follow-up visits; it was detected by amplifying the cryptic plasmid sequence by polymerase chain reaction (PCR) using two sets of primers: KL5/KL6 and KL1/KL2. Infection was defined as a positive PCR result using either set of primers at any time during the study. Cox proportional risk models were used for evaluating the association between the appearance of infection and a group of independent variables. Results Base line C. trachomatis infection frequency was 28% (n = 61). Most females infected by C. trachomatis were infected by multiple types of HPV (77.42%), greater prevalence occurring in females infected with HPV-16 (19.18%), followed by HPV-58 (17.81%). It was observed that females having had the most sexual partners (HR = 6.44: 1.59–26.05 95%CI) or infection with multiple types of HPV (HR = 2.85: 1.22–6.63 95%CI) had the greatest risk of developing C. trachomatis. Conclusions The study provides data regarding the epidemiology of C. trachomatis /HPV coinfection in different population groups of Colombian females and contributes towards understanding the natural history of C. trachomatis infection. © 2016 Quinónez-Calvache et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0147504
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18946
dc.language.isoengspa
dc.relation.citationEndPage14
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage1
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 11
dc.relation.ispartofPLoS ONE, ISSN: 1932-6203, Vol. 11/No. 1 (2016); pp. 1-14spa
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0147504&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/spa
dc.source.bibliographicCitationSmith, J.S., Bosetti, C., Munoz, N., Herrero, R., Bosch, F.X., Eluf-Neto, J., Chlamydia trachomatis and invasive cervical cancer: A pooled analysis of the IARC multicentric case-control study (2004) International Journal of Cancer Journal International Du Cancer, 111 (3), pp. 431-439. , Epub 2004/06/29. PMID: 15221973spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectAdolescentespa
dc.subjectEnvejecidospa
dc.subjectIdentificación de bacteriasspa
dc.subjectClamidiasisspa
dc.subjectAnálisis de cohortesspa
dc.subjectPareja sexual concurrentespa
dc.subjectEstudio controladospa
dc.subjectCurso de Enfermedadspa
dc.subjectHacer un seguimientospa
dc.subjectAmplificación de genesspa
dc.subjectPoblación de alto riesgospa
dc.subjectHumanospa
dc.subjectVirus del papiloma humano tipo 16spa
dc.subjectVirus del papiloma humano tipo 18spa
dc.subjectVirus del papiloma humano tipo 31spa
dc.subjectVirus del papiloma humano tipo 33spa
dc.subjectVirus del papiloma humano tipo 45spa
dc.subjectVirus del papiloma humano tipo 58spa
dc.subjectRiesgo de infecciónspa
dc.subjectEstudio clínico principalspa
dc.subjectInfección mixtaspa
dc.subjectMorbosidadspa
dc.subjectNo humanospa
dc.subjectInfección por virus del papilomaspa
dc.subjectReacción en cadena de la polimerasaspa
dc.subjectPredominiospa
dc.subjectAnálisis de secuenciaspa
dc.subjectInfecciones por clamidiaspa
dc.subjectCoinfecciónspa
dc.subjectAislamiento y Purificaciónspa
dc.subjectpapilomaviridaespa
dc.subjectInfecciones por virus del papilomaspa
dc.subjectSexualidadspa
dc.subjectAdulto jovenspa
dc.subjectPrevalencespa
dc.subjectParejas sexualesspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordAdulteng
dc.subject.keywordAdolescenteng
dc.subject.keywordFemaleeng
dc.subject.keywordMiddle Agedeng
dc.subject.keywordAgedeng
dc.subject.keywordBacterium Identificationeng
dc.subject.keywordHumanseng
dc.subject.keywordChlamydiasiseng
dc.subject.keywordCohort Analysiseng
dc.subject.keywordConcurrent Sexual Partnershipeng
dc.subject.keywordControlled Studyeng
dc.subject.keywordDisease Courseeng
dc.subject.keywordFollow Upeng
dc.subject.keywordGene Amplificationeng
dc.subject.keywordHigh Risk Populationeng
dc.subject.keywordHumaneng
dc.subject.keywordHuman Papillomavirus Type 16eng
dc.subject.keywordHuman Papillomavirus Type 18eng
dc.subject.keywordHuman Papillomavirus Type 31eng
dc.subject.keywordHuman Papillomavirus Type 33eng
dc.subject.keywordHuman Papillomavirus Type 45eng
dc.subject.keywordHuman Papillomavirus Type 58eng
dc.subject.keywordInfection Riskeng
dc.subject.keywordMajor Clinical Studyeng
dc.subject.keywordMixed Infectioneng
dc.subject.keywordMorbidityeng
dc.subject.keywordNonhumaneng
dc.subject.keywordPapillomavirus Infectioneng
dc.subject.keywordPolymerase Chain Reactioneng
dc.subject.keywordPrevalenceeng
dc.subject.keywordSequence Analysiseng
dc.subject.keywordChlamydia Infectionseng
dc.subject.keywordCoinfectioneng
dc.subject.keywordIsolation And Purificationeng
dc.subject.keywordPapillomaviridaeeng
dc.subject.keywordPapillomavirus Infectionseng
dc.subject.keywordSexualityeng
dc.subject.keywordYoung Adulteng
dc.subject.keywordSexual Partnerseng
dc.subject.keywordChlamydia Trachomatislat
dc.subject.lembInfecciones por chlamydiaspa
dc.subject.lembEnfermedades bacterianasspa
dc.subject.lembPapilomaspa
dc.titleChlamydia trachomatis frequency in a cohort of HPV-infected colombian womenspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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