Ítem
Acceso Abierto
Systemic Lupus Erythematosus 2014
Título de la revista
Autores
Anaya, Juan-Manuel
Shoenfeld, Yehuda
Cervera, Richard
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Fecha
2014
Directores
ISSN de la revista
Título del volumen
Editor
Universidad del Rosario
Citations
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Resumen
Abstract
Systemic lupus erythematosus (SLE, lupus) is the prototype
of systemic autoimmune disease (AD). Immune system
activation in SLE is characterized by exaggerated B-cell and
T-cell responses and loss of immune tolerance against selfantigens.
Production and defective elimination of antibodies,
circulation and tissue deposition of immune complexes, and
complement and cytokine activation contribute to clinical
manifestations that range from fatigue and joint pain to
severe, life-threatening organ damage
