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Spatio-temporal dynamics of Plasmodium falciparum transmission within a spatial unit on the Colombian Pacific Coast.

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dc.creatorKnudson, Angelicaspa
dc.creatorGonzalez-Casabianca, Felipespa
dc.creatorFeged Rivadeneira, Alejandrospa
dc.creatorPedreros, Maria Fernandaspa
dc.creatorAponte, Samandaspa
dc.creatorOlaya, Adrianaspa
dc.creatorCastillo, Carlos Fspa
dc.creatorMancilla, Elviraspa
dc.creatorPiamba-Dorado, Andersonspa
dc.creatorSanchez-Pedraza, Ricardospa
dc.creatorSalazar-Terreros, Myriam Janethspa
dc.creatorLucchi, Naomispa
dc.creatorUdhayakumar, Venkatachalamspa
dc.creatorJacob, Chrisspa
dc.creatorPance, Alenaspa
dc.creatorCarrasquilla, Manuelaspa
dc.creatorApraez, Giovannispa
dc.creatorAngel, Jairo Andresspa
dc.creatorRayner, Julian Cspa
dc.creatorCorredor, Vladimirspa
dc.date.accessioned2020-06-11T13:22:08Z
dc.date.available2020-06-11T13:22:08Z
dc.date.created2020spa
dc.description.abstractAs malaria control programmes concentrate their efforts towards malaria elimination a better understanding of malaria transmission patterns at fine spatial resolution units becomes necessary. Defining spatial units that consider transmission heterogeneity, human movement and migration will help to set up achievable malaria elimination milestones and guide the creation of efficient operational administrative control units. Using a combination of genetic and epidemiological data we defined a malaria transmission unit as the area contributing 95% of malaria cases diagnosed at the catchment facility located in the town of Guapi in the South Pacific Coast of Colombia. We provide data showing that P. falciparum malaria transmission is heterogeneous in time and space and analysed, using topological data analysis, the spatial connectivity, at the micro epidemiological level, between parasite populations circulating within the unit. To illustrate the necessity to evaluate the efficacy of malaria control measures within the transmission unit in order to increase the efficiency of the malaria control effort, we provide information on the size of the asymptomatic reservoir, the nature of parasite genotypes associated with drug resistance as well as the frequency of the Pfhrp2/3 deletion associated with false negatives when using Rapid Diagnostic Tests.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/s41598-020-60676-1
dc.identifier.issn2045-2322
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25032
dc.language.isoeng
dc.publisherNature Publishing Groupspa
dc.relation.citationEndPage3756
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage3756
dc.relation.citationTitleScientific reports
dc.relation.citationVolumeVol. 10
dc.relation.ispartofScientific reports, ISSN:2045-2322, Vol.10, No.1 (2020); pp. 3756-3756spa
dc.relation.urihttps://www.nature.com/articles/s41598-020-60676-1.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordUnderstanding of malariaspa
dc.subject.keywordTransmission heterogeneityspa
dc.subject.keywordGenetic and epidemiological dataspa
dc.titleSpatio-temporal dynamics of Plasmodium falciparum transmission within a spatial unit on the Colombian Pacific Coast.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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