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Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate

dc.creatorMastronardi, CAspa
dc.creatorPillai, Espa
dc.creatorPineda, DAspa
dc.creatorMartinez, AFspa
dc.creatorLopera, Fspa
dc.creatorVelez, JIspa
dc.creatorPalacio, JDspa
dc.creatorPatel, Hspa
dc.creatorEasteal, Sspa
dc.creatorAcosta, MTspa
dc.creatorCastellanos, FXspa
dc.creatorMuenke, Mspa
dc.creatorArcos-Burgos, M.spa
dc.date.accessioned2020-08-19T14:45:34Z
dc.date.available2020-08-19T14:45:34Z
dc.date.created2015-11-24spa
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurodevelopmental disorder with serious long-term repercussions. Despite being one of the most common cognitive disorders, the clinical diagnosis of ADHD is based on subjective assessments of perceived behaviors. Endophenotypes (neurobiological markers that cosegregate and are associated with an illness) are thought to provide a more powerful and objective framework for revealing the underlying neurobiology than syndromic psychiatric classification. Here, we present the results of applying genetic linkage and association analyses to neuropsychological endophenotypes using microsatellite and single nucleotide polymorphisms. We found several new genetic regions linked and/or associated with these endophenotypes, and others previously associated to ADHD, for example, loci harbored in the LPHN3, FGF1, POLR2A, CHRNA4 and ANKFY1 genes. These findings, when compared with those linked and/or associated to ADHD, suggest that these endophenotypes lie on shared pathways. The genetic information provided by this study offers a novel and complementary method of assessing the genetic causes underpinning the susceptibility to behavioral conditions and may offer new insights on the neurobiology of the disorder.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/mp.2015.172
dc.identifier.issnISSN: 1359-4184
dc.identifier.issnEISSN: 1476-5578
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28071
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage1440
dc.relation.citationIssueNo. 10
dc.relation.citationStartPage1434
dc.relation.citationTitleMolecular Psychiatry
dc.relation.citationVolumeVol. 21
dc.relation.ispartofMolecular Psychiatry, ISSN: 1359-4184;EISSN: 1476-5578, Vol.21, No.10 (2016); pp. 1434–1440spa
dc.relation.urihttps://www.nature.com/articles/mp2015172.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceMolecular Psychiatryspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPredictive markersspa
dc.subject.keywordPsychiatric disordersspa
dc.titleLinkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolatespa
dc.title.TranslatedTitleAnálisis de vinculación y asociación de endofenotipos de TDAH en genealogías extendidas y multigeneracionales de un aislado genéticospa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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