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Genetic polymorphisms in cytokine genes in colombian patients with ocular toxoplasmosis

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dc.creatorNaranjo-Galvis, C. A.spa
dc.creatorde-la-Torre, Alejandraspa
dc.creatorMantilla-Muriel, L. E.spa
dc.creatorBeltrán-Angarita, L.spa
dc.creatorElcoroaristizabal-Martín, X.spa
dc.creatorMcLeod, R.spa
dc.creatorAlliey-Rodriguez, N.spa
dc.creatorBegeman, I. J.spa
dc.creatorde Mesa, C. Lópezspa
dc.creatorGómez-Marín, J. E.spa
dc.creatorSepúlveda-Arias, J. C.spa
dc.date.accessioned2020-05-26T00:11:16Z
dc.date.available2020-05-26T00:11:16Z
dc.date.created2018spa
dc.description.abstractToxoplasmosis is caused by infection with the protozoan parasite Toxoplasma gondii, which has the capacity to infect all warm-blooded animals worldwide. Toxoplasmosis is a major cause of visual defects in the Colombian population; however, the association between genetic polymorphisms in cytokine genes and susceptibility to ocular toxoplasmosis has not been studied in this population. This work evaluates the associations between polymorphisms in genes coding for the cytokines tumor necrosis factor alpha (TNF-?) (rs1799964, rs1800629, rs1799724, rs1800630, and rs361525), interleukin 1? (IL-1?) (rs16944, rs1143634, and rs1143627), IL-1? (rs1800587), gamma interferon (IFN-?) (rs2430561), and IL-10 (rs1800896 and rs1800871) and the presence of ocular toxoplasmosis (OT) in a sample of a Colombian population (61 patients with OT and 116 healthy controls). Genotyping was performed with the 'dideoxynucleotide (ddNTP) primer extension' technique. Functional-effect predictions of single nucleotide polymorphisms (SNPs) were done by using FuncPred. A polymorphism in the IL-10 gene promoter (-1082G/A) was significantly more prevalent in OT patients than in controls (P = 1.93e-08; odds ratio [OR] = 5.27e+03; 95% confidence interval [CI] = 3.18 to 8.739; Bonferroni correction [BONF] = 3.48e-07). In contrast, haplotype 'AG' of the IL-10 gene promoter polymorphisms (rs1800896 and rs1800871) was present at a lower frequency in OT patients (P = 7e-04; OR = 0.10; 95% CI = 0.03 to 0.35). The +874A/T polymorphism of IFN-? was associated with OT (P = 3.37e-05; OR = 4.2; 95% CI = 2.478 to 7.12; BONF = 6.07e-04). Haplotype 'GAG' of the IL-1? gene promoter polymorphisms (rs1143634, rs1143627, and rs16944) appeared to be significantly associated with OT (P = 0.0494). The IL-10, IFN-?, and IL-1? polymorphisms influence the development of OT in the Colombian population. ©2018 American Society for Microbiology.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/IAI.00597-17
dc.identifier.issn10985522
dc.identifier.issn00199567
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24292
dc.language.isoengspa
dc.publisherAmerican Society for Microbiologyspa
dc.relation.citationIssueNo. 4
dc.relation.citationTitleInfection and Immunity
dc.relation.citationVolumeVol. 86
dc.relation.ispartofInfection and Immunity, ISSN:10985522, 00199567, Vol.86, No.4 (2018)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85044342120&doi=10.1128%2fIAI.00597-17&partnerID=40&md5=8b1a8cc1f3e3eb06235618b5b1df6845spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGamma interferonspa
dc.subject.keywordoculareng
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordInterleukin 10spa
dc.subject.keywordgeneticeng
dc.subject.keywordInterleukin 1alphaspa
dc.subject.keywordInterleukin 1betaspa
dc.subject.keywordRibonucleasespa
dc.subject.keywordTumor necrosis factorspa
dc.subject.keywordCytokinespa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordCase control studyspa
dc.subject.keywordColombianspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDna extractionspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGene interactionspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMonocytespa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordPromoter regionspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordAllelespa
dc.subject.keywordColombiaspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordGene regulatory networkspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordAllelesspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordCytokinesspa
dc.subject.keywordDisease susceptibilityspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGene regulatory networksspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordPromoter regionseng
dc.subject.keywordToxoplasmosiseng
dc.subject.keywordCytokinesspa
dc.subject.keywordOcular toxoplasmosisspa
dc.subject.keywordSingle nucleotide polymorphismsspa
dc.subject.keywordSusceptibilityspa
dc.titleGenetic polymorphisms in cytokine genes in colombian patients with ocular toxoplasmosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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