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Relation of sensory peripheral neuropathy in sjögren syndrome to Anti-Ro/SSA

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dc.creatorScofield, Amanda Kylespa
dc.creatorRadfar, Lidaspa
dc.creatorIce, John A.spa
dc.creatorVista, Evanspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorHouston, Glenspa
dc.creatorLewis, Davidspa
dc.creatorStone, Donald U.spa
dc.creatorChodosh, Jamesspa
dc.creatorHefner, Kimberlyspa
dc.creatorLessard, Christopher J.spa
dc.creatorMoser, Kathy L.spa
dc.creatorScofield, Robert Halspa
dc.date.accessioned2020-05-25T23:56:04Z
dc.date.available2020-05-25T23:56:04Z
dc.date.created2012spa
dc.description.abstractBackground: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Methods: Eight-eight patients attending a dry eyesYdry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay. Results: Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (W2 = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti- La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (W2 = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sjögren syndrome. Conclusions: Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion. Copyright © 2012 by Lippincott Williams and amp; Wilkins.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1097/RHU.0b013e3182675e4f
dc.identifier.issn10761608
dc.identifier.issn15367355
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22310
dc.language.isoengspa
dc.relation.citationEndPage293
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage290
dc.relation.citationTitleJournal of Clinical Rheumatology
dc.relation.citationVolumeVol. 18
dc.relation.ispartofJournal of Clinical Rheumatology, ISSN:10761608, 15367355, Vol.18, No.6 (2012); pp. 290-293spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84868231431&doi=10.1097%2fRHU.0b013e3182675e4f&partnerID=40&md5=f59d15ed7dc3986d5ffcd4517f1d789dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCyanocobalaminspa
dc.subject.keywordantinucleareng
dc.subject.keywordLa antibodyspa
dc.subject.keywordRo antibodyspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordCyanocobalamin deficiencyspa
dc.subject.keywordDisease associationspa
dc.subject.keywordEnzyme linked microtiter plate assayspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordImmunodiffusionspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordNeurologic examinationspa
dc.subject.keywordPeripheral neuropathyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProprioceptionspa
dc.subject.keywordSensory neuropathyspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordVibrationspa
dc.subject.keywordVitamin blood levelspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAntibodieseng
dc.subject.keywordAutoantigensspa
dc.subject.keywordCohort studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordImmunodiffusionspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPeripheral nervous system diseasesspa
dc.subject.keywordRibonucleoproteinsspa
dc.subject.keywordSjogren's syndromespa
dc.subject.keywordVitamin b 12spa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordPeripheral neuropathyspa
dc.subject.keywordSjögren syndromespa
dc.subject.keywordVitamin b 12spa
dc.titleRelation of sensory peripheral neuropathy in sjögren syndrome to Anti-Ro/SSAspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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