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The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and metaanalysis

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dc.creatorMeneses Echávez, José Francisco
dc.creatorGonzález-Jiménez, Emilio
dc.creatorRío-Valle, Jacqueline Schmidt
dc.creatorCorrea Bautista, Jorge Enrique
dc.creatorIzquierdo, Mikel
dc.creatorRamírez-Vélez, Robinson
dc.creator.googleMeneses-Echávez, José Franciscospa
dc.creator.googleJiménez, E.G.spa
dc.creator.googleSchmidt Río-Valle, Jacquelinespa
dc.creator.googleCorrea-Bautista, J.E.spa
dc.creator.googleIzquierdo, M.spa
dc.creator.googleRamírez-Vélez, R.spa
dc.date.accessioned2020-05-11T22:47:43Z
dc.date.available2020-05-11T22:47:43Z
dc.date.created2016-08-25
dc.date.issued2016
dc.description.abstractBackground: Insulin-like growth factors (IGFs) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancer-related outcomes and survival, although its effects on IGF are not well understood. This meta-analysis aimed to determine the effects of exercise in modulating IGFs system in breast cancer survivors. Methods: Databases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials.gov, SPORTDiscus, LILACS and Scopus were systematically searched up to November 2014. Effect estimates were calculated through a random-effects model of meta-analysis according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I 2 test. Risk of bias and methodological quality were evaluated using the PEDro score. Results: Five randomized controlled trials (n=235) were included. Most women were post-menopausal. High-quality and low risk of bias were found (mean PEDro score=6.2±1). Exercise resulted in significant improvements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin resistance (P<0.05). Non-significant differences were found for Glucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No evidence of publication bias was detected by Eggeŕs test (p=0.12). Conclusions: Exercise improved IGFs in breast cancer survivors. These findings provide novel insight regarding the molecular effects of exercise on tumoral microenvironment, apoptosis and survival in breast cancer survivors. © 2016 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12885-016-2733-z
dc.identifier.issn1471-2407
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21960
dc.language.isoengspa
dc.relation.citationTitleBMC Cancer
dc.relation.citationVolumeVol. 16
dc.relation.ispartofBMC Cancer, ISSN: 1471-2407 Vol. 16, (Agosto 2016); 10 ppspa
dc.relation.urihttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2733-zspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcIncidencia & prevención de la enfermedadspa
dc.subject.keywordConfidence intervalspa
dc.subject.keywordELISAeng
dc.subject.keywordGFeng
dc.subject.keywordIGFBPeng
dc.subject.keywordIGFBPeng
dc.subject.keywordMDeng
dc.subject.keywordPEDroeng
dc.subject.keywordRCTeng
dc.subject.keywordSDeng
dc.subject.keywordBiological markerspa
dc.subject.keywordSomatomedinspa
dc.titleThe insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and metaanalysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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