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The high immunogenicity induced by modified sporozoites' malarial peptides depends on their phi (?) and psi (?) angles

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dc.creatorPatarroyo, Manuel E.spa
dc.creatorBermudez, Adrianaspa
dc.creatorAlba, Martha P.spa
dc.date.accessioned2020-05-26T00:02:39Z
dc.date.available2020-05-26T00:02:39Z
dc.date.created2012spa
dc.description.abstractThe importance of CSP- and STARP-derived ? and ? dihedral angles in mHABP structure was analysed by 1H NMR in the search for molecules which can be included as components of a first-line-of-defence Plasmodium falciparum sporozoite multi-epitope vaccine against the most lethal form of human malaria. Most of the aforementioned dihedral angles were left-hand-like polyproline type II (PPIIL) structures whilst others had right-hand-like ?-helix (?R), thus allowing mHABPS to fit better into MHCII molecules and thereby form an appropriate pMHCII complex and also establish the H-bonds which stabilise such complex and by this means induce an appropriate immune response. This information has great implications for vaccine development, malaria being one of them. © 2012 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2012.10.088
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23512
dc.language.isoengspa
dc.relation.citationEndPage86
dc.relation.citationIssueNo. 43862
dc.relation.citationStartPage81
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 429
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.429, No.43862 (2012); pp. 81-86spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84870391900&doi=10.1016%2fj.bbrc.2012.10.088&partnerID=40&md5=0342f3570a2423c967218557f5ec1927spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBinding proteinspa
dc.subject.keywordsecondaryeng
dc.subject.keywordHigh activity binding peptidespa
dc.subject.keywordMajor histocompatibility antigen class 2spa
dc.subject.keywordProlinespa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordSporozoite threonine and asparagine rich proteinspa
dc.subject.keywordSporozoite vaccinespa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAlpha helixspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordArticlespa
dc.subject.keywordComplex formationspa
dc.subject.keywordHydrogen bondspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein structurespa
dc.subject.keywordProton nuclear magnetic resonancespa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordAotus trivirgatusspa
dc.subject.keywordHla-dr beta-chainsspa
dc.subject.keywordHumansspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordNuclear magnetic resonanceeng
dc.subject.keywordPeptide fragmentsspa
dc.subject.keywordPeptidesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtein structureeng
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordSporozoitesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keyword? and ? anglesspa
dc.subject.keywordAntimalarial-vaccinespa
dc.subject.keywordHladr?* moleculesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPre-erythrocyte stagespa
dc.titleThe high immunogenicity induced by modified sporozoites' malarial peptides depends on their phi (?) and psi (?) anglesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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