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Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

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dc.creatorHernández, E. C.spa
dc.creatorSuárez, C. F.spa
dc.creatorParra, C. A.spa
dc.creatorPatarroyo, M. A.spa
dc.creatorPatarroyo, M. E.spa
dc.date.accessioned2020-08-19T14:44:09Z
dc.date.available2020-08-19T14:44:09Z
dc.date.created2005-09-29spa
dc.description.abstractIn order to characterize immunoglobulin heavy?chain variable (IGHV ) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non?human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae . Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae . Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.1399-0039.2005.00491.x
dc.identifier.issnISSN: 2059-2302
dc.identifier.issnEISSN: 2059-2310
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27837
dc.language.isoengspa
dc.publisherJohn Wiley & Sonsspa
dc.relation.citationEndPage649
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage640
dc.relation.citationTitleHLA, Tissue Antigens
dc.relation.citationVolumeVol. 66
dc.relation.ispartofHLA, Tissue Antigens, ISSN: 2059-2302;EISSN: 2059-2310, Vol.66, No.6 (December 2005); pp. 640-649spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1399-0039.2005.00491.xspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceHLA, Tissue Antigensspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAnimal modelspa
dc.subject.keywordAotusspa
dc.subject.keywordIGHVspa
dc.subject.keywordMolecular evolutionspa
dc.subject.keywordNew World monkeyspa
dc.titleIdentification of five different IGHV gene families in owl monkeys (Aotus nancymaae)spa
dc.title.TranslatedTitleIdentificación de cinco familias de genes IGHV diferentes en monos búho (Aotus nancymaae)spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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