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Interleukin-1? polymorphisms in Colombian patients with autoimmune rheumatic diseases

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dc.creatorCamargo, J Fspa
dc.creatorCorrea, P Aspa
dc.creatorCastiblanco, Jspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-08-19T14:44:30Z
dc.date.available2020-08-19T14:44:30Z
dc.date.created2004-10-07spa
dc.description.abstractInterleukin-1 beta (IL-1?) exerts a range of inflammatory and immunomodulatory activities that are important in host defense and autoimmune response. The IL-1? gene, located on chromosome 2 (2q13), is polymorphic. The influence of its polymorphism on 355 patients with autoimmune rheumatic diseases was examined. To this effect, 172 patients with rheumatoid arthritis (RA), 114 with systemic lupus erythematosus (SLE), and 69 with primary Sjögren's syndrome (pSS) were studied. The control group consisted of 392 matched healthy individuals. Genotyping of IL-1? single-nucleotide polymorphisms (SNPs) at positions ?511 (C/T) and +3953 (C/T) was performed by the polymerase chain reaction-restriction fragment length polymorphism technique. In addition, levels of IL-1? were measured by immunoassay in supernatants of lipopolysaccharide (LPS)-stimulated and nonstimulated peripheral blood monocytes (PBM) obtained from 19 homozygous individuals for the three most common IL-1? likely haplotypes, all belonging to the control group. Allele+3953T was protective for SLE (odds ratio (OR)=0.57, 95% confidence intervals (CI)=0.34–0.88, P=0.01) as was the haplotype ?511C+3953T (OR=0.43, 95%CI=0.25–0.74, pc=0.006). The latter was associated with a lower LPS-stimulated-PBM IL-1? secretion. Results suggest that IL-1? polymorphism influences the susceptibility to acquire SLE in our population. The protective association might be explained by the observed inhibitory effect of IL-1? +3953T allele on the secretion of IL-1? under inflammatory circumstances.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/sj.gene.6364133
dc.identifier.issnISSN: 1466-4879
dc.identifier.issnEISSN: 1476-5470
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27895
dc.language.isoengspa
dc.publisherNature Publishing Groupspa
dc.relation.citationEndPage614
dc.relation.citationIssueNo. 8
dc.relation.citationStartPage609
dc.relation.citationTitleGenes and Immunity
dc.relation.citationVolumeVol. 5
dc.relation.ispartofGenes and Immunity, ISSN: 1466-4879;EISSN: 1476-5470, Vol.5, No.8 (2004); pp. 609–614spa
dc.relation.urihttps://www.nature.com/articles/6364133.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceGenes and Immunityspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordInterleukin-1 betaspa
dc.subject.keywordPolymorphismsspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.titleInterleukin-1? polymorphisms in Colombian patients with autoimmune rheumatic diseasesspa
dc.title.TranslatedTitlePolimorfismos de interleucina-1? en pacientes colombianos con enfermedades reumáticas autoinmunesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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