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Solo Metadatos
Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism
dc.creator | Anaya, Juan-Manuel | |
dc.creator | Corre, Paula A. | spa |
dc.creator | Herrera, Monica | spa |
dc.creator | Eskdale, Joyce | spa |
dc.creator | Gallagher, Grant | spa |
dc.date.accessioned | 2020-08-28T15:48:09Z | |
dc.date.available | 2020-08-28T15:48:09Z | |
dc.date.created | 2002 | spa |
dc.description.abstract | Objective. To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren’s syndrome (pSS). Methods. Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. Results. IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 ± 6.7 vs 2.5 ± 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (< 9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. Conclusion. Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism. (J Rheumatol 2002;29:1874–6). | eng |
dc.format.mimetype | application/pdf | |
dc.identifier.issn | ISSN: 0315-162X | |
dc.identifier.issn | EISSN: 1499-2752 | |
dc.identifier.uri | https://repository.urosario.edu.co/handle/10336/28416 | |
dc.language.iso | eng | spa |
dc.publisher | The Journal of Rheumatology Publishing | spa |
dc.relation.citationEndPage | 1876 | |
dc.relation.citationIssue | No. 9 | |
dc.relation.citationStartPage | 1874 | |
dc.relation.citationTitle | The Journal of Rheumatology | |
dc.relation.citationVolume | Vol. 29 | |
dc.relation.ispartof | The Journal of Rheumatology, ISSN: 0315-162X ; EISSN: 1499-2752, Vol. 29, No. 9 (2002); pp. 1874-1876 | spa |
dc.relation.uri | https://www.jrheum.org/content/jrheum/29/9/1874.full.pdf | spa |
dc.rights.accesRights | info:eu-repo/semantics/openAccess | |
dc.rights.acceso | Abierto (Texto Completo) | spa |
dc.source | The Journal of Rheumatology | spa |
dc.source.instname | instname:Universidad del Rosario | |
dc.source.reponame | reponame:Repositorio Institucional EdocUR | |
dc.subject.keyword | Sjögren’s Syndrome | spa |
dc.subject.keyword | Interleukin 10 | spa |
dc.subject.keyword | Anti-Ro Antibodies | spa |
dc.subject.keyword | Anti-La Antibodies | spa |
dc.subject.keyword | Rheumatoid Factor | spa |
dc.subject.keyword | Polymorphism | spa |
dc.subject.keyword | Genetics | spa |
dc.title | Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism | spa |
dc.title.TranslatedTitle | La interleucina 10 (IL-10) influye en la respuesta autoinmune en el síndrome de Sjögren primario y está relacionada con el polimorfismo del gen IL-10 | spa |
dc.type | article | eng |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | |
dc.type.spa | Artículo | spa |