Ítem
Acceso Abierto

Immunopathogenesis of ocular toxoplasmosis and implications for treatment

Mostrar el registro sencillo de la publicación
dc.creatorGomez Marin, Jorgespa
dc.creatorDe La Torre Cifuentes, Ligia Alejandraspa
dc.creatorVargas-Montes, Mónicaspa
dc.date.accessioned2024-01-31T18:26:42Z
dc.date.available2024-01-31T18:26:42Z
dc.date.created2023-11-29spa
dc.date.issued2023spa
dc.descriptionIntroduction: Ocular toxoplasmosis appears after primary infection or during the reactivation of chronic infection by the protozoa Toxoplasma gondii. The risk of ocular involvement and the heterogeneity of clinical manifestations, their complications, and the probability of recurrences are linked to polymorphisms in immune response-related genes, cytokine networks, lymphocyte subpopulation, and parasite virulence factors. Appropriate clinical management and evidence-based advisory recommendations for patients require a clear understanding of the immunopathological mechanisms of this parasitic disease.Areas covered: Narrative review of the scientific literature in human ocular toxoplasmosis related to parasitological and immunological characteristics, genetic polymorphisms linked to ocular involvement, and the clinical correlations of the cytokinome in aqueous humor and experiments with peripheral blood mononuclear cells.Expert Opinion/Commentary: The greater severity in people infected by South American strains is partly explained by parasite protein kinases interfering with the effector immune functions of inter-feron-gamma, resulting in lower antiparasitic activity and more significant inflammation. Future thera-pies should point to the increase in IFN-? production (for example, by stimulating CD4+ memory T cells subset). Thus, immune-based interventions could be promising in inducing an appropriate response for treating and preventing ocular damage and recurrences. Drugs targeting tissue cysts responsible for reactivations are a current priority.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttp://doi.org/10.1080/17469899.2023.2279178 spa
dc.identifier.issn1746-9899spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/42128
dc.language.isoengspa
dc.publisherUniversidad del Rosariospa
dc.relation.urihttps://www.tandfonline.com/doi/epdf/10.1080/17469899.2023.2279178?needAccess=truespa
dc.rightsAttribution-NonCommercial-NoDerivs 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.sourceExpert Review of Ophthalmologyspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectOcular toxoplasmosisspa
dc.subjectcytokinesspa
dc.subjectlymphocyte subpopulationsspa
dc.subjectuveitisspa
dc.subjectToxoplasma gondiispa
dc.subjectvirulencespa
dc.subjectinterferon gammaspa
dc.titleImmunopathogenesis of ocular toxoplasmosis and implications for treatmentspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Immunopathogenesis of ocular toxoplasmosis.pdf
Tamaño:
2.84 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos