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Chromosomal instability in farmers exposed to pesticides: High prevalence of clonal and non-clonal chromosomal alterations

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dc.creatorCepeda, Sebastianspa
dc.creatorForero-Castro, Maribelspa
dc.creatorCárdenas-Nieto, Dianaspa
dc.creatorMartínez Agüero, Magdalena Maríaspa
dc.creatorRondón-Lagos, Milenaspa
dc.date.accessioned2020-05-26T00:00:39Z
dc.date.available2020-05-26T00:00:39Z
dc.date.created2020spa
dc.description.abstractIntroduction: An important economic activity in Colombia is agricultural production and farmers are frequently exposed to pesticides. Occupational exposure to pesticides is associated with an increased incidence of various diseases, including cancer, Parkinson’s disease, Alzheimer’s disease, reproductive disorders, and birth defects. However, although high genotoxicity is associated with these chemicals, information about the type and frequency of specific chromosomal alterations (CAs) and the level of chromosomal instability (CIN) induced by exposure to pesticides is scarce or absent. Methods: In this study, CAs and CIN were assessed in peripheral blood lymphocytes (PBLs) from five farmers occupationally exposed to pesticides and from five unexposed individuals using GTG-banding and molecular cytogenetic analysis. Results: A significant increase in clonal and non-clonal chromosomal alterations was observed in pesticide-exposed individuals compared with unexposed individuals (510±12,2 vs 73±5,7, respectively; p less than 0.008). Among all CAs, monosomies and deletions were more frequently observed in the exposed group. Also, a high frequency of fragilities was observed in the exposed group. Conclusion: Together, these findings suggest that exposure to pesticides could be associated with CIN in PBLs and indicate the need for the establishment of educational programs on safety precautions when handling pesticides, such as wearing gloves, masks and boots, changing clothes and maintaining proper hygiene, among others. Further evaluation in other similar studies that include a greater number of individuals exposed to pesticides is necessary. © 2020 Cepeda et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2147/RMHP.S230953
dc.identifier.issn11791594
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23252
dc.language.isoengspa
dc.publisherDove Medical Press Ltdspa
dc.relation.citationEndPage110
dc.relation.citationStartPage97
dc.relation.citationTitleRisk Management and Healthcare Policy
dc.relation.citationVolumeVol. 13
dc.relation.ispartofRisk Management and Healthcare Policy, ISSN:11791594, Vol.13,(2020); pp. 97-110spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85079648106&doi=10.2147%2fRMHP.S230953&partnerID=40&md5=8279ba237476735181241e31fcc9e19aspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordPesticidespa
dc.subject.keywordAdultspa
dc.subject.keywordAgricultural workerspa
dc.subject.keywordArticlespa
dc.subject.keywordChromatid aberrationspa
dc.subject.keywordChromosomal instabilityspa
dc.subject.keywordChromosome analysisspa
dc.subject.keywordChromosome banding patternspa
dc.subject.keywordChromosome breakagespa
dc.subject.keywordChromosome deletionspa
dc.subject.keywordChromosome mutationspa
dc.subject.keywordClinical articlespa
dc.subject.keywordClonal variationspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordFluorescence in situ hybridizationspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGenotoxicityspa
dc.subject.keywordHigh risk populationspa
dc.subject.keywordHumanspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMonosomyspa
dc.subject.keywordNumerical chromosome aberrationspa
dc.subject.keywordOccupational exposurespa
dc.subject.keywordOccupational hazardspa
dc.subject.keywordPeripheral lymphocytespa
dc.subject.keywordPesticide sprayingspa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordRisk factorspa
dc.subject.keywordStructural chromosome aberrationspa
dc.subject.keywordChromosomal instabilityspa
dc.subject.keywordClonal chromosomal alterationspa
dc.subject.keywordNon-clonal chromosomal alterationspa
dc.subject.keywordOccupational exposurespa
dc.subject.keywordPesticidesspa
dc.titleChromosomal instability in farmers exposed to pesticides: High prevalence of clonal and non-clonal chromosomal alterationsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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