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Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorSany, J.spa
dc.creatorCouret, M.spa
dc.creatorCombe, B.spa
dc.creatorDaures JP.spa
dc.date.accessioned2020-08-19T14:41:06Z
dc.date.available2020-08-19T14:41:06Z
dc.date.created1991spa
dc.description.abstractOne hundred and ninety-one patients with severe rheumatoid arthritis (RA) were included in a prospective open longterm study of the safety, efficacy and maintenance of methotrexate (MTX) treatment. The mean duration of MTX treatment was 19 +/- 13.2 (3-58) months; the mean weekly dose of MTX was 10.2 +/- 0.2 mg. Analysis of the 191 patients in an intent-to-treat manner showed a significant improvement of all the clinical variables and a decrease of erythrocyte sedimentation rate with a steroid sparing effect. The probability of continuing MTX therapy for up to 2 years was 65% and for up to 5 years was 46%. Adverse effects of MTX occurred in 37.1% of the patients, but only 15.7% discontinued MTX permanently.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN: 0315-162X
dc.identifier.issnEISSN: 1499-2752
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27135
dc.language.isoengspa
dc.publisherEurope PMCspa
dc.relation.citationEndPage1327
dc.relation.citationIssueNo. 9
dc.relation.citationStartPage1323
dc.relation.citationTitleJournal of Rheumatology
dc.relation.citationVolumeVol. 18
dc.relation.ispartofJournal of Rheumatology, ISSN: 0315-162X;EISSN: 1499-2752, Vol.18, No.9 (31 Agosto 1991); pp.1323-1327spa
dc.relation.urihttps://europepmc.org/article/med/1757932spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceJournal of Rheumatologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSafetyspa
dc.subject.keywordEfficacyspa
dc.subject.keywordMaintenancespa
dc.titleTreatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 casesspa
dc.title.TranslatedTitleTratamiento de la artritis reumatoide con metotrexato: un estudio prospectivo abierto a largo plazo de 191 casosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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