Ítem
Acceso Abierto

Using graph theory to assess the interaction between cerebral function, brain hemodynamics and systemic variables in premature infants

Mostrar el registro sencillo de la publicación
dc.creatorHendrikx, Driesspa
dc.creatorThewissen, Liesbethspa
dc.creatorSmits, Annespa
dc.creatorNaulaers, Gunnarspa
dc.creatorAllegaert, Karelspa
dc.creatorVan Huffel, Sabinespa
dc.creatorCaicedo Dorado, Alexander
dc.date.accessioned2020-08-19T14:41:13Z
dc.date.available2020-08-19T14:41:13Z
dc.date.created2018-08-09spa
dc.description.abstractGraphs can be used to describe a great variety of real-world situations and have therefore been used extensively in different fields. In the present analysis, we use graphs to study the interaction between cerebral function, brain hemodynamics, and systemic variables in premature neonates. We used data from a propofol dose-finding and pharmacodynamics study as a model in order to evaluate the performance of the graph measures to monitor signal interactions. Concomitant measurements of heart rate, mean arterial blood pressure, arterial oxygen saturation, regional cerebral oxygen saturation—measured by means of near-infrared spectroscopy—and electroencephalography were performed in 22 neonates undergoing INSURE (intubation, surfactant administration, and extubation). The graphs used to study the interaction between these signal modalities were constructed using the RBF kernel. Results indicate that propofol induces a decrease in the signal interaction up to 90 minutes after propofol administration, which is consistent with clinical observations published previously. The clinical recovery phase is mainly determined by the EEG dynamics, which were observed to recover much slower compared to the other modalities. In addition, we found a more pronounced loss in cerebral-systemic interactions with increasing propofol dose.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2018/6504039
dc.identifier.issnISSN: 1076-2787
dc.identifier.issnEISSN: 1099-0526
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27171
dc.language.isoengspa
dc.publisherHindawi Publishing Corporationspa
dc.publisherWileyspa
dc.relation.citationTitleComplexity
dc.relation.citationVolumeVol. 2018
dc.relation.ispartofComplexity, ISSN: 1076-2787;EISSN: 1099-0526, Vol.2018 (2018); 16 pp. spa
dc.relation.urihttp://downloads.hindawi.com/journals/complexity/2018/6504039.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceComplexityspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordBrainspa
dc.subject.keywordCerebral functionspa
dc.titleUsing graph theory to assess the interaction between cerebral function, brain hemodynamics and systemic variables in premature infantsspa
dc.title.TranslatedTitleUso de la teoría de grafos para evaluar la interacción entre la función cerebral, la hemodinámica cerebral y las variables sistémicas en bebés prematurosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
6504039.pdf
Tamaño:
2.99 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos