Ítem
Solo Metadatos
Distribución del valor p para la prueba t en estudios de no-inferioridad con muestras paralelas
| dc.creator | Monterrey P.A. | spa |
| dc.date.accessioned | 2020-05-25T23:55:44Z | |
| dc.date.available | 2020-05-25T23:55:44Z | |
| dc.date.created | 2017 | spa |
| dc.description.abstract | In randomized controlled clinical trials, treatment efficacy is considered as its capability to produce beneficial effects. Efficacy of an experimental treatment is usually established comparing its effectiveness respect to a placebo or comparing with the effect of an active control treatment. The first stage to determine effectiveness of a new treatment is placebo-controlled trial, and, as a second stage, a superiority trial will compare new treatment with a treatment uniformly accepted as a standard one. Sometimes the use of a placebo control is considered unethical; in such a case, a non-inferiority trial may be appropriate. In non-inferiority the new treatment dont need to be superior to a control, it is enough that it doesn't be unacceptably worse and additionally to be better than placebo. This assert rules the construction of non-inferiority hypothesis, which is based in a non-inferiority margin; in its determination is necessary to consider both statistical reasoning and clinical judgement. The possibility to claim incorrectly non-inferiority is one of the methodological flaws in non-inferiority studies and is related with the determination of non-inferiority margin. Two samples t-test is the statistical criteria to analyze non-inferiority hypothesis when mean value is the parameter to measure treatments efficacy. The objective of present report was to obtain and to characterize the p-value probability distribution for t-test in non-inferiority designs and to establish the relationship between this distribution and test's power function, as a result a characterization of the effect of sample size and non-inferiority margin over test sensibility was obtained, in addition an application of p-value distribution to meta-analysis was done introducing a criteria to analyze the effect of a particular study in results integration. | eng |
| dc.format.mimetype | application/pdf | |
| dc.identifier.issn | 2574306 | |
| dc.identifier.uri | https://repository.urosario.edu.co/handle/10336/22192 | |
| dc.language.iso | eng | spa |
| dc.publisher | Universidad de La Habana | spa |
| dc.relation.citationEndPage | 265 | |
| dc.relation.citationIssue | No. 3 | |
| dc.relation.citationStartPage | 259 | |
| dc.relation.citationTitle | Investigacion Operacional | |
| dc.relation.citationVolume | Vol. 38 | |
| dc.relation.ispartof | Investigacion Operacional, ISSN:2574306, Vol.38, No.3 (2017); pp. 259-265 | spa |
| dc.relation.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019629932&partnerID=40&md5=d6bfac17a0337f1b58c0ba70aa5f2466 | spa |
| dc.rights.accesRights | info:eu-repo/semantics/openAccess | |
| dc.rights.acceso | Abierto (Texto Completo) | spa |
| dc.source.instname | instname:Universidad del Rosario | spa |
| dc.source.reponame | reponame:Repositorio Institucional EdocUR | spa |
| dc.subject.keyword | Meta-analysys | spa |
| dc.subject.keyword | Non-inferiority | spa |
| dc.subject.keyword | Non-inferiority margin | spa |
| dc.subject.keyword | P-values distribution | spa |
| dc.subject.keyword | T-test | spa |
| dc.subject.keyword | Test power | spa |
| dc.title | Distribución del valor p para la prueba t en estudios de no-inferioridad con muestras paralelas | spa |
| dc.type | article | eng |
| dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | |
| dc.type.spa | Artículo | spa |
