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Synthetic evaluation of standard and microwave-assisted solid phase peptide synthesis of a long chimeric peptide derived from four Plasmodium falciparum proteins

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dc.creatorVarela, Yahson F.spa
dc.creatorMurcia, Magnolia Vanegasspa
dc.creatorPatarroyo, Manuel Elkinspa
dc.date.accessioned2020-05-25T23:57:12Z
dc.date.available2020-05-25T23:57:12Z
dc.date.created2018spa
dc.description.abstractAn 82-residue-long chimeric peptide was synthesised by solid phase peptide synthesis (SPPS), following the Fmoc protocol. Microwave (MW) radiation-assisted synthesis was compared to standard synthesis using low loading (0.20 mmol/g) of polyethylene glycol (PEG) resin. Similar synthetic difficulties were found when the chimeric peptide was obtained via these two reaction conditions, indicating that such difficulties were inherent to the sequence and could not be resolved using MW; by contrast, the number of coupling cycles and total reaction time became reduced whilst crude yield and percentage recovery after purification were higher for MW radiation-assisted synthesis. © 2018 by the authors.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/molecules23112877
dc.identifier.issn14203049
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22628
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 11
dc.relation.citationTitleMolecules
dc.relation.citationVolumeVol. 23
dc.relation.ispartofMolecules, ISSN:14203049, Vol.23, No.11 (2018)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85056274571&doi=10.3390%2fmolecules23112877&partnerID=40&md5=36bfcdd1ab5457a95db7f9d7dbaa86c2spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordPeptidespa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordChemistryspa
dc.subject.keywordDrug effectspa
dc.subject.keywordMetabolismspa
dc.subject.keywordMicrowave radiationspa
dc.subject.keywordMolecular weightspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordSolid phase synthesisspa
dc.subject.keywordSpectroscopyspa
dc.subject.keywordSynthesisspa
dc.subject.keywordMicrowavesspa
dc.subject.keywordMolecular weightspa
dc.subject.keywordPeptidesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordSolid-phase synthesis techniquesspa
dc.subject.keywordSpectrum analysisspa
dc.subject.keywordChimeric peptidespa
dc.subject.keywordCouplingspa
dc.subject.keywordFmoc protocolspa
dc.subject.keywordMicrowave radiationspa
dc.subject.keywordSolid phase peptide synthesisspa
dc.titleSynthetic evaluation of standard and microwave-assisted solid phase peptide synthesis of a long chimeric peptide derived from four Plasmodium falciparum proteinsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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