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The role of chromosomal instability in cancer and therapeutic responses

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dc.creatorVargas-Rondón, Natalia
dc.creatorVillegas Gálvez, Victoria Eugenia
dc.creatorRondón-Lagos, Milena
dc.creator.googleVargas-Rondón, Nataliaspa
dc.creator.googleVillegas, Victoria E.spa
dc.creator.googleRondón-Lagos, Milenaspa
dc.date.accessioned2020-03-31T20:48:34Z
dc.date.available2020-03-31T20:48:34Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractCancer is one of the leading causes of death, and despite increased research in recent years, control of advanced-stage disease and optimal therapeutic responses remain elusive. Recent technological improvements have increased our understanding of human cancer as a heterogeneous disease. For instance, four hallmarks of cancer have recently been included, which in addition to being involved in cancer development, could be involved in therapeutic responses and resistance. One of these hallmarks is chromosome instability (CIN), a source of genetic variation in either altered chromosome number or structure. CIN has become a hot topic in recent years, not only for its implications in cancer diagnostics and prognostics, but also for its role in therapeutic responses. Chromosomal alterations are mainly used to determine genetic heterogeneity in tumors, but CIN could also reveal treatment efficacy, as many therapies are based on increasing CIN, which causes aberrant cells to undergo apoptosis. However, it should be noted that contradictory findings on the implications of CIN for the therapeutic response have been reported, with some studies associating high CIN with a better therapeutic response and others associating it with therapeutic resistance. Considering these observations, it is necessary to increase our understanding of the role CIN plays not only in tumor development, but also in therapeutic responses. This review focuses on recent studies that suggest possible mechanisms and consequences of CIN in different disease types, with a primary focus on cancer outcomes and therapeutic responses. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/cancers10010004
dc.identifier.issn2072-6694
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21328
dc.language.isoengspa
dc.relation.citationTitleCancers
dc.relation.citationVolumeVol. 10
dc.relation.ispartofCancers, ISSN:2072-6694, Vol. 10 (2018)spa
dc.relation.urihttps://www.mdpi.com/2072-6694/10/1/4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationNicholson, J.M., Cimini, D., Cancer karyotypes: Survival of the fittest (2013) Front. Oncol, 3, p. 148. , [CrossRef] [PubMed]spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectEpidermal Growth Factor Receptor 2spa
dc.subjectEstrogen Receptorspa
dc.subjectSmad2 Proteinspa
dc.subjectSmad4 Proteinspa
dc.subjectAcute Lymphoblastic Leukemiaspa
dc.subjectAneuploidyspa
dc.subjectBladder Cancerspa
dc.subjectBreast Cancerspa
dc.subjectCancer Diagnosisspa
dc.subjectCancer Growthspa
dc.subjectCancer Prognosisspa
dc.subjectCancer Therapyspa
dc.subjectChromosomal Instabilityspa
dc.subjectChromosome Aberrationspa
dc.subjectChromosome Segregationspa
dc.subjectColorectal Cancerspa
dc.subjectEndometrium Cancerspa
dc.subjectGene Functionspa
dc.subjectGene Interactionspa
dc.subjectGene Mutationspa
dc.subjectGenetic Heterogeneityspa
dc.subjectGenetic Variationspa
dc.subjectHigh Hyperdiploid Acute Lymphoblastic Leukemiaspa
dc.subjectHumanspa
dc.subjectMalignant Neoplasmspa
dc.subjectMultiple Myelomaspa
dc.subjectNon Recurrent Chromosomal Alterationspa
dc.subjectNonhumanspa
dc.subjectProstate Cancerspa
dc.subjectReviewspa
dc.subjectTherapy Resistancespa
dc.subjectTreatment Outcomespa
dc.subjectTreatment Responsespa
dc.subjectTumor Growthspa
dc.subjectUterine Cervix Cancerspa
dc.subjectFactor de Crecimiento Epidérmico Receptor 2spa
dc.subjectReceptor de estrógenosspa
dc.subjectLa proteína Smad2spa
dc.subjectLa proteína smad4spa
dc.subject.ddcEnfermedadesspa
dc.subject.lembNeoplasiaspa
dc.subject.lembInestabilidad cromosómicaspa
dc.titleThe role of chromosomal instability in cancer and therapeutic responsesspa
dc.typerevieweng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaRevisiónspa
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