Ítem
Acceso Abierto
GLP-1 Analogues in the Neurobiology of Addiction
Título de la revista
Autores
Rodríguez-Quintana, Jesús
Calderon Ospina, Carlos Alberto
Rojas-Rodríguez, Luis Carlos
Carrillo-Vaca, Liliana
Forero-Cárdenas, Sara
Tibaduiza-Arévalo, Lucía Catalina
Barrera-Carreño, Samuel
Olaya-Bonilla, Santiago Arturo
Marquez-Meneses, Juan David
Fecha
2025-06-01
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MDPI
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Resumen
Abstract
Glucagon-like peptide-1 receptor agonists, originally developed for the treatment of metabolic disorders, have recently emerged as promising candidates for the management of substance use disorders. This review synthesizes preclinical, clinical, and translational evidence on the effects of glucagon-like peptide-1 receptor agonists across addiction models involving alcohol, nicotine, psychostimulants, and opioids. In animal studies, glucagon-like peptide-1 receptor agonists consistently reduce drug intake, attenuate dopamine release in reward circuits, and decrease relapse-like behavior. Clinical and observational studies provide preliminary support for these findings, particularly among individuals with comorbid obesity or insulin resistance. However, several translational barriers remain, including limited blood–brain barrier penetration, species differences in pharmacokinetics, and variability in treatment response due to genetic and metabolic factors. Ethical considerations and methodological heterogeneity further complicate clinical translation. Future directions include the development of central nervous system penetrant analogues, personalized medicine approaches incorporating pharmacogenomics, and rigorously designed trials in diverse populations. Glucagon-like peptide-1 receptor agonists may offer a novel therapeutic strategy that addresses both metabolic and neuropsychiatric dimensions of addiction, warranting further investigation to define their role in the evolving landscape of substance use disorder treatment.
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Keywords
Química orgánica , Glucagon-like peptide-1 receptor agonists , Substance-related disorders , Brain–gut axis , Alcoholism , Tobacco use disorder , Cocaine-related disorders , Amphetamine-related disorders , Opioid-related disorders , Blood–brain barrier , Translational research , Biomedical
