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TCR-contacting residues orientation and HLA-DR?* binding preference determine long-lasting protective immunity against malaria

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dc.creatorAlba, Martha P.spa
dc.creatorSuarez, Carlos F.spa
dc.creatorVarela, Yahsonspa
dc.creatorPatarroyo, Manuel A.spa
dc.creatorBermudez, Adrianaspa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-05-26T00:02:42Z
dc.date.available2020-05-26T00:02:42Z
dc.date.created2016spa
dc.description.abstractFully-protective, long-lasting, immunological (FPLLI) memory against Plasmodium falciparum malaria regarding immune protection-inducing protein structures (IMPIPS) vaccinated into monkeys previously challenged and re-challenged 60 days later with a lethal Aotus monkey-adapted P. falciparum strain was found to be associated with preferential high binding capacity to HLA-DR?1* allelic molecules of the major histocompatibility class II (MHC-II), rather than HLA-DR?3*, ?4*, ?5* alleles. Complete PPIIL 3D structure, a longer distance (26.5 Å ± 1.5 Å) between residues perfectly fitting into HLA-DR?1*PBR pockets 1 and 9, a gauche? rotamer orientation in p8 TCR-contacting polar residue and a larger volume of polar p2 residues was also found. This data, in association with previously-described p3 and p7 apolar residues having gauche+ orientation to form a perfect MHC-II-peptide-TCR complex, determines the stereo-electronic and topochemical characteristics associated with FPLLI immunological memory. © 2016 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2016.06.115
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23515
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage660
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage654
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 477
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.477, No.4 (2016); pp. 654-660spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84979648915&doi=10.1016%2fj.bbrc.2016.06.115&partnerID=40&md5=c174acdba3728a8e15ab2bee01df5a63spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBinding proteinspa
dc.subject.keywordinnateeng
dc.subject.keywordt-celleng
dc.subject.keywordHla drb4 antigenspa
dc.subject.keywordHla drb5 antigenspa
dc.subject.keywordImmunogenic protection inducing peptide structurespa
dc.subject.keywordMajor histocompatibility antigen class 2spa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordMultiprotein complexspa
dc.subject.keywordParasite antibodyspa
dc.subject.keywordQuininespa
dc.subject.keywordRecombinant proteinspa
dc.subject.keywordT lymphocyte receptorspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordHla dr antigenspa
dc.subject.keywordLymphocyte antigen receptorspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAntibody responsespa
dc.subject.keywordAntibody titerspa
dc.subject.keywordAntigen bindingspa
dc.subject.keywordArticlespa
dc.subject.keywordBinding affinityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordImmunogeneticsspa
dc.subject.keywordImmunological memoryspa
dc.subject.keywordMalaria falciparumspa
dc.subject.keywordMonkey modelspa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProvocation testspa
dc.subject.keywordAnimalspa
dc.subject.keywordAotusspa
dc.subject.keywordBinding sitespa
dc.subject.keywordChemistryspa
dc.subject.keywordImmunological memoryspa
dc.subject.keywordImmunologyspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordMalariaspa
dc.subject.keywordStructure activity relationspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAotus trivirgatusspa
dc.subject.keywordBinding sitesspa
dc.subject.keywordHla-dr beta-chainsspa
dc.subject.keywordImmunityeng
dc.subject.keywordImmunologic memoryspa
dc.subject.keywordMalariaspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordReceptorseng
dc.subject.keywordStructure-activity relationshipspa
dc.subject.keywordAntimalarial-vaccinespa
dc.subject.keywordImmunological memoryspa
dc.subject.keywordMhc-iispa
dc.subject.keywordRotamer-orientationspa
dc.subject.keywordT-cell-receptorspa
dc.titleTCR-contacting residues orientation and HLA-DR?* binding preference determine long-lasting protective immunity against malariaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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