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Caracterización clínica y epidemiológica del carcinoma lobulillar en mujeres con cáncer de mama: serie de casos en el Hospital Universitario Mayor Mederi, 2021 - 2023

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dc.contributor.advisorRubiano Forero, Wilson
dc.contributor.advisorDe la Peña, Jairo Antonio
dc.contributor.advisorDaza Vergara, José Alejandro
dc.creatorPatiño Muñoz, Ángela María
dc.creator.degreeEspecialista en Mastologíaspa
dc.creator.degreeEspecialista en Mastología
dc.creator.degreeLevelMaestría
dc.date.accessioned2025-03-26T13:58:17Z
dc.date.available2025-03-26T13:58:17Z
dc.date.created2025-03-17
dc.descriptionIntroducción: El carcinoma lobulillar infiltrante (CLI) es una variante poco frecuente del cáncer de mama, caracterizada por su crecimiento infiltrativo y diagnóstico tardío. En Colombia, hay poca información sobre su comportamiento clínico y epidemiológico, lo que dificulta el desarrollo de estrategias efectivas de detección y tratamiento. Objetivo: Determinar la prevalencia, y describir las características clínicas y sociodemográficas de las mujeres con cáncer de mama subtipo CLI atendidas en el Hospital Universitario Mayor Mederi entre 2021 hasta 2023. Metodología Estudio en dos fases: primero, corte transversal descriptivo para estimar la prevalencia de CLI en 178 mujeres con cáncer de mama; seguido de una serie de casos con las 6 pacientes con subtipo CLI. Resultados y Discusión: La prevalencia de CLI fue del 3.37%, inferior a la reportada en la literatura global entre 10 hasta 15%. Adicionalmente, de estas pacientes, el 50% debutó con enfermedad metastásica con afectación predominante en hueso, pleura y sistema nervioso central. La mortalidad fue del 100% entre 1 a 6 años posterior al diagnóstico. Conclusiones y recomendaciones : El CLI tiene alta mortalidad en estadios avanzados, lo que enfatiza la necesidad de diagnóstico temprano y tamizaje genético en poblaciones de alto riesgo. Se recomienda ampliar estudios con mayor tamaño muestral y seguimiento prolongado para optimizar estrategias terapéuticas y mejorar el pronóstico de estas pacientes.
dc.description.abstractIntroduction: Infiltrating lobular carcinoma (ILC) is a rare variant of breast cancer, characterized by its infiltrative growth and late diagnosis. In Colombia, there is little information about its clinical and epidemiological behavior, which makes it difficult to develop effective detection and treatment strategies. Objective: Determine the prevalence, and describe the clinical and sociodemographic characteristics of women with CLI subtype breast cancer treated at the Mayor Mederi University Hospital between 2021 and 2023. Methodology Study in two phases: first, a descriptive cross-sectional section to estimate the prevalence of CLI in 178 women with breast cancer; followed by a case series with the 6 patients with CLI subtype. Results and discussion: The prevalence of CLI was 3.37%, lower than that reported in the global literature between 10 and 15%. Additionally, of these patients, 50% debuted with metastatic disease with predominant involvement in bone, pleura and central nervous system. Mortality was 100% between 1 and 6 years after diagnosis. Conclusions and recommendations: CLI has high mortality in advanced stages, emphasizing the need for early diagnosis and genetic screening in high-risk populations. It is recommended to expand studies with a larger sample size and prolonged follow-up to optimize therapeutic strategies and improve the prognosis of these patients.
dc.format.extent83 pp
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_45150
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/45150
dc.language.isospa
dc.publisherUniversidad del Rosario
dc.publisher.departmentEscuela de Medicina y Ciencias de la Salud
dc.publisher.programEspecialización en Mastología
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)
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dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectCarcinoma lobulillar
dc.subjectNeoplasias mamarias
dc.subjectPrevalencia
dc.subject.keywordLobular carcinoma
dc.subject.keywordBreast neoplasms
dc.subject.keywordPrevalence
dc.titleCaracterización clínica y epidemiológica del carcinoma lobulillar en mujeres con cáncer de mama: serie de casos en el Hospital Universitario Mayor Mederi, 2021 - 2023
dc.title.TranslatedTitleClinical and epidemiological characterization of lobular carcinoma in women with breast cancer: Series of cases at the Mayor Mederi University Hospital, 2021 - 2023
dc.typemasterThesis
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de grado
local.department.reportEscuela de Medicina y Ciencias de la Salud
local.regionesBogotá
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