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Long-term feeding of the cis-9,trans-11 isomer of conjugated linoleic acid reinforces the specific immune response in rats

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dc.creatorRamírez Santana, Heily Carolina
dc.creatorCastellote, Cristinaspa
dc.creatorCastell, Margaridaspa
dc.creatorRivero, Montserratspa
dc.creatorRodri?guez-Palmero, Mariaspa
dc.creatorFranch, A?ngelsspa
dc.creatorPe?rez-Cano, Francisco Jspa
dc.date.accessioned2020-08-19T14:45:38Z
dc.date.available2020-08-19T14:45:38Z
dc.date.created2009-01spa
dc.description.abstractSeveral effects on the immune system have been ascribed to the cis9,trans11 conjugated linoleic acid (CLA) isomer. We studied whether feeding a diet enriched with an 80:20 CLA isomer mix of cis9,trans11 and trans10,cis12 CLA from gestation to adulthood affects the capacity of adult rats to achieve a specific immune response. Pregnant Wistar rats were fed a 1% CLA diet or a control diet beginning on d 7 of gestation. Weaned pups received the same diet as dams until they were 15 wk old. Rats from both groups were immunized with ovalbumin (OVA) when they were 9 wk old. Dietary CLA enhanced splenocyte OVA-specific proliferation by approximately 50% (P < 0.05) and decreased the mitogen-induced proliferative responses of these cells by approximately 10-20% (P < 0.05). The diminished splenocyte proliferative response was accompanied by a lower interleukin-2 secretion (P < 0.05). Long-term CLA supplementation did not increase serum, spleen, or mesenteric lymph node production of OVA-specific antibodies (Ab) or the number of spleen anti-OVA Ab-secreting cells. Interestingly, dietary CLA increased intestinal anti-OVA IgA production by approximately 75% (P < 0.05). In conclusion, a 1% CLA diet administered from gestation to adulthood enhanced specific systemic cell-mediated immunity as well as the mucosal IgA immune response, whereas it downregulated the polyclonal activation of the immune system. These data support the long-term effects of dietary cis9,trans11 CLA isomer on the immune system.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3945/jn.108.097428
dc.identifier.issnISSN: 0022-3166
dc.identifier.issnEISSN: 1541-6100
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28080
dc.language.isoengspa
dc.publisherAmerican Society for Nutritionspa
dc.relation.citationEndPage81
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage76
dc.relation.citationTitleJournal of Nutrition
dc.relation.citationVolumeVol. 139
dc.relation.ispartofJournal of Nutrition, ISSN: 0022-3166; EISSN: 1541-6100, Vol.139, No.1 (2009); pp. 76-81spa
dc.relation.urihttps://watermark.silverchair.com/76.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAp8wggKbBgkqhkiG9w0BBwagggKMMIICiAIBADCCAoEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMhtQK7-DavS56k19SAgEQgIICUquXGkP04spobARLoxaWY99N0FF1tPUHhTac3DkLP8Kqdw0rd4ySnf6mWWomEdaafeKYJPviSE3Rf9lEBzYUGRLhOrqaTr3Xv_a5AOyrodMJ2F2PAs-XUUUxsVmSCoDuDawYN6UegDO-UgLLUHJEonbwOmheUDXmxGgGkrbaSV6DISEdc7bbuYpY4k4qHgJmT6Np_ScH1QTSGIdBPsIh1cBJnF8Kewh_wDx75vpHFn6-AEX-FhaHFwAg7EEJnpsM6o2MqkANomiXVMxMuVaVDCAKLRD2z3lFn_w9Mtq13jVzeyMsKAod_T4pyiYtuJDQuyXgrx1mbT9lQihrrpUetXmrSBuETOKhu6PMD2F2LVJGV2cBQNQ2ENT3uNNhEKI47SxBAkgABU6UkG52XnVoSEJA4wQiwG09J5HbzliwVHbXMf6ac_y9xS5W-SumWoGMwzkQx7ZHLvse_oRf_gWsmRr0ub8sFCTZb1Mwaked0dgqomITb_DiBTUMVr3_d_uZsiMjeCcqTJOwFZlFhs2r9EZ1qqZZnx4BSVWheDn7n_uHibeHev67Jvfac8buxkJti-qzf_-cYgtwJSuSwHf-xUZDS1baXAL-Bv1dbTDHUm-fXV4VGrV3URP2UVrW7au1eva3pOKdIxoK_aAOWKKkawZZzgan5UsIGKr5UGZsLUmr8m0WqYmuryCQRqDkTyb-My8ioFoQT6LiZN_lQ39QrzN2MnrxT0bjyQ6ilZL2wTS9fGy3HwehSdO2fFbmXS0ENNJiYJkHk9DRItVqg3PwgZ1QVQspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceJournal of Nutritionspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPregnancyspa
dc.subject.keywordLinoleic acidalspa
dc.subject.keywordDesleukinspa
dc.subject.keywordImmune responsespa
dc.subject.keywordDietspa
dc.subject.keywordAdulspa
dc.subject.keywordTgrowth factorimmune systemspa
dc.subject.keywordImmunizationspa
dc.titleLong-term feeding of the cis-9,trans-11 isomer of conjugated linoleic acid reinforces the specific immune response in ratsspa
dc.title.TranslatedTitleLa alimentación a largo plazo del isómero cis-9, trans-11 del ácido linoleico conjugado refuerza la respuesta inmunitaria específica en ratasspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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