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Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients

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dc.creatorForero D.A.spa
dc.creatorArboleda G.spa
dc.creatorYunis J.J.spa
dc.creatorPardo R.spa
dc.creatorArboleda H.spa
dc.date.accessioned2020-05-25T23:56:22Z
dc.date.available2020-05-25T23:56:22Z
dc.date.created2006spa
dc.description.abstractAnalysis of genetic susceptibility factors for Alzheimer's disease (AD) in populations with different genetic and environmental background may be useful to understand AD etiology. There are few genetic association studies of AD in Latin America. In the present work, we analyzed polymorphisms in 3 candidate genes; the LDL receptor related protein-1, the microtubule-associated protein Tau and the serotonin transporter genes in a sample of 106 Colombian AD patients and 97 control subjects. We did not find a significant allelic or genotypic association with any of the three polymorphisms analyzed using different statistical analysis, including a neural network model or different sample stratifications. To date, APOE polymorphisms are the only genetic risk factors identified for AD in the Colombian population. It may be factible that future combination of high-throughput genotyping platforms and multivariate analysis models may lead to the identification of other genetic susceptibility factors for AD in the Colombian population. © Springer-Verlag 2005.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s00702-005-0388-z
dc.identifier.issn3009564
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22408
dc.language.isoengspa
dc.relation.citationEndPage1262
dc.relation.citationIssueNo. 9
dc.relation.citationStartPage1253
dc.relation.citationTitleJournal of Neural Transmission
dc.relation.citationVolumeVol. 113
dc.relation.ispartofJournal of Neural Transmission, ISSN:3009564, Vol.113, No.9 (2006); pp. 1253-1262spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33747873955&doi=10.1007%2fs00702-005-0388-z&partnerID=40&md5=28cb48c1fdbdcca35a6226a7697b028dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordApolipoprotein Espa
dc.subject.keywordLow density lipoprotein receptor related protein 1spa
dc.subject.keywordProteinspa
dc.subject.keywordSerotonin transporterspa
dc.subject.keywordTau proteinspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAllelespa
dc.subject.keywordAlzheimer diseasespa
dc.subject.keywordArticlespa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease associationspa
dc.subject.keywordDNA polymorphismspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMicrotubulespa
dc.subject.keywordMultivariate analysisspa
dc.subject.keywordNerve cell networkspa
dc.subject.keywordPopulation researchspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSouth and Central Americaspa
dc.subject.keywordStatistical analysisspa
dc.subject.keywordStratificationspa
dc.subject.keywordAgedspa
dc.subject.keywordAllelesspa
dc.subject.keywordAlzheimer Diseasespa
dc.subject.keywordApolipoprotein E4spa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGene Frequencyspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordLDL-Receptor Related Protein 1spa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordMinisatellite Repeatsspa
dc.subject.keywordReverse Transcriptase Polymerase Chain Reactionspa
dc.subject.keywordRisk Factorsspa
dc.subject.keywordSerotonin Plasma Membrane Transport Proteinsspa
dc.subject.keywordTau Proteinsspa
dc.subject.keywordAlzheimer's diseasespa
dc.subject.keywordColombiaspa
dc.subject.keywordGenetic associationspa
dc.titleAssociation study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patientsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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