Ítem
Acceso Abierto

Protection against malaria is conferred by passive transferring rabbit F(ab)2' antibody fragments, induced by Plasmodium falciparum MSP-1 site-directed designed pseudopeptide-BSA conjugates assessed in a rodent model

Mostrar el registro sencillo de la publicación
dc.creatorLozano J.M.spa
dc.creatorLesmes L.P.spa
dc.creatorGallego G.M.spa
dc.creatorPatarroyo M.E.spa
dc.date.accessioned2020-05-25T23:57:09Z
dc.date.available2020-05-25T23:57:09Z
dc.date.created2011spa
dc.description.abstractF(ab)2'-immunoglobulin (Ig) fragments induced by site-directed designed immunogens are emerging as novel tools of potential utility in the treatment of clinical episodes of transmissible diseases such as malaria. Immunogens based on reduced amide pseudopeptides based on site-directed molecular modifications represent structural probes that could be considered as novel vaccine candidates, as we have previously demonstrated. We have obtained F(ab)2'-Ig rabbit antibodies induced against the N-terminal sequence of the native Merozoite Surface Protein-1 (MSP-1) of Plasmodium falciparum and a set of five MSP-1-derived reduced amide pseudopeptides. Pseudopeptides were designed for inducing functional neutralizing mono-specific polyclonal antibodies with potential applications in the control of malaria. Following a classical enzyme immunoglobulin fractionation, F(ab)2'-Ig fragments were tested for their ability to suppress blood-stage parasitemia by passive immunization in malaria-infected mice. Some of these fragments proved totally effective in suppressing a lethal blood-stage challenge infection and others reduced malarial parasitemia. These data suggest that protection against Plasmodium yoelii malaria following passive transfer of structurally well-defined ?-strand F(ab)2'-Ig fragments can be associated with specific immunoglobulins induced by site-directed designed MSP-1 reduced amide pseudopeptides. © 2010 Elsevier Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.molimm.2010.11.007
dc.identifier.issn1615890
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22617
dc.language.isoengspa
dc.relation.citationEndPage669
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage657
dc.relation.citationTitleMolecular Immunology
dc.relation.citationVolumeVol. 48
dc.relation.ispartofMolecular Immunology, ISSN:1615890, Vol.48, No.4 (2011); pp. 657-669spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-78650597098&doi=10.1016%2fj.molimm.2010.11.007&partnerID=40&md5=8408a7c04ada5bfd99a80db0fc15786dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBovine serum albuminspa
dc.subject.keywordbovineeng
dc.subject.keywordImmunoglobulin f(ab')2 fragmentspa
dc.subject.keywordPeptide vaccinespa
dc.subject.keywordPolyclonal antibodyspa
dc.subject.keywordPseudopeptidespa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAmino terminal sequencespa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordIn vivo studyspa
dc.subject.keywordMalariaspa
dc.subject.keywordMalaria controlspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordPassive immunizationspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein analysisspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntibodieseng
dc.subject.keywordAntibodieseng
dc.subject.keywordCattlespa
dc.subject.keywordComputational biologyspa
dc.subject.keywordDisease modelseng
dc.subject.keywordImmunizationeng
dc.subject.keywordImmunoglobulin fab fragmentsspa
dc.subject.keywordMalariaspa
dc.subject.keywordMerozoite surface protein 1spa
dc.subject.keywordMicespa
dc.subject.keywordMiceeng
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordMutagenesiseng
dc.subject.keywordPeptidesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPlasmodium yoeliispa
dc.subject.keywordProtein structureeng
dc.subject.keywordRabbitsspa
dc.subject.keywordSerum albumineng
dc.subject.keywordMusspa
dc.subject.keywordOryctolagus cuniculusspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPlasmodium yoeliispa
dc.subject.keywordRodentiaspa
dc.subject.keywordAntibody-(fab)'2spa
dc.subject.keywordImmunotherapyspa
dc.subject.keywordNeutralizing antibodyspa
dc.subject.keywordRodent malaria modelspa
dc.subject.keywordSynthetic vaccinespa
dc.titleProtection against malaria is conferred by passive transferring rabbit F(ab)2' antibody fragments, induced by Plasmodium falciparum MSP-1 site-directed designed pseudopeptide-BSA conjugates assessed in a rodent modelspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
1-s2-0-S0161589010006243-main.pdf
Tamaño:
2.16 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos