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Expression, polymorphism analysis, reticulocyte binding and serological reactivity of two Plasmodium vivax MSP-1 protein recombinant fragments

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dc.creatorEspinosa, Ana Mar??aspa
dc.creatorSierra, Adriana Yanettspa
dc.creatorBarrero, Carlos Albertospa
dc.creatorCepeda, Libia Alexandraspa
dc.creatorCantor, Elvia Mar??aspa
dc.creatorLombo, Tania Bibianaspa
dc.creatorGuzmán, Fannyspa
dc.creatorAvila, Sandra Julietaspa
dc.creatorPatarroyo, Manuel A.
dc.date.accessioned2020-08-28T15:48:13Z
dc.date.available2020-08-28T15:48:13Z
dc.date.created2003-03-07spa
dc.description.abstractAmong the four parasite species causing malaria in humans, Plasmodium vivax prevails on both the Asian and the American continents. Several antigens from this parasite’s erythrocytic stages have been characterised and some of them are considered to be good vaccine candidates. The P. vivax merozoite surface protein-1 (PvMSP-1) is a 200 kDa antigen, thought to mediate the initial contact between the merozoite and the erythrocyte. An effective blockage of this interaction could be important in anti-malarial vaccine design. This study analyses the genetic polymorphism, binding to both reticulocytes and erythrocytes, antigenicity and immunogenicity of two recombinant proteins belonging to the 33 kDa PvMSP-1 proteolytic fragment. Both regions showed very low genetic variation, bound reticulocytes with higher affinity than erythrocytes, were recognised by naturally P. vivax-infected patient sera and were immunogenic when used to immunise rabbits, making them good vaccine candidates against P. vivax, to be further preclinically tested in the Aotus monkey model.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/S0264-410X(02)00660-6
dc.identifier.issnISSN: 0264-410X
dc.identifier.issnEISSN: 1873-2518
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28446
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage1043
dc.relation.citationIssueNo. 11–12
dc.relation.citationStartPage1033
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 21
dc.relation.ispartofVaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol. 21, No. 11–12 (7 March 2003); pp. 1033-1043spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0264410X02006606?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceVaccinespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordMSP-1spa
dc.subject.keywordBindingspa
dc.subject.keywordPolymorphismspa
dc.titleExpression, polymorphism analysis, reticulocyte binding and serological reactivity of two Plasmodium vivax MSP-1 protein recombinant fragmentsspa
dc.title.TranslatedTitleExpresión, análisis de polimorfismo, unión de reticulocitos y reactividad serológica de dos fragmentos recombinantes de la proteína Plasmodium vivax MSP-1spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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