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Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review

dc.creatorAmaya-Amaya, Jennyspa
dc.creatorCalixto, Omar-Javierspa
dc.creatorSaade-Lemus, Sandraspa
dc.creatorCalvo-Paramo, Enriquespa
dc.creatorMantilla, Ruben-Dariospa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:00:59Z
dc.date.available2020-05-26T00:00:59Z
dc.date.created2015spa
dc.description.abstractObjective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease. © 2014 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.semarthrit.2014.09.006
dc.identifier.issn490172
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23295
dc.language.isoengspa
dc.publisherW.B. Saundersspa
dc.relation.citationEndPage498
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage489
dc.relation.citationTitleSeminars in Arthritis and Rheumatism
dc.relation.citationVolumeVol. 44
dc.relation.ispartofSeminars in Arthritis and Rheumatism, ISSN:490172, Vol.44, No.5 (2015); pp. 489-498spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84926337355&doi=10.1016%2fj.semarthrit.2014.09.006&partnerID=40&md5=22637736616e6b1725766f9fbe03ae9bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntinuclear antibodyspa
dc.subject.keywordrheumatoideng
dc.subject.keywordC reactive proteinspa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAdultspa
dc.subject.keywordAge distributionspa
dc.subject.keywordArticlespa
dc.subject.keywordAsiaspa
dc.subject.keywordClinical evaluationspa
dc.subject.keywordColombiaspa
dc.subject.keywordComputer assisted tomographyspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordDisease durationspa
dc.subject.keywordEchographyspa
dc.subject.keywordEuropespa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMexicospa
dc.subject.keywordNon erosive rheumatoid arthritisspa
dc.subject.keywordOnset agespa
dc.subject.keywordPopulation researchspa
dc.subject.keywordPrevalencespa
dc.subject.keywordPriority journalspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSouth and central americaspa
dc.subject.keywordSystematic review (topic)spa
dc.subject.keywordVisual analog scalespa
dc.subject.keywordX rayspa
dc.subject.keywordBonespa
dc.subject.keywordImmunologyspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordRadiographyspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordAdultspa
dc.subject.keywordArthritiseng
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordBone and bonesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordComputed tomographyspa
dc.subject.keywordErosionsspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordUltrasonographyspa
dc.subject.keywordX-rayspa
dc.titleDoes non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature reviewspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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