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Clinical and nerve conduction features in Guillain? Barré syndrome associated with Zika virus infection in Cúcuta, Colombia

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dc.creatorUncini, A.spa
dc.creatorGonzález?Bravo, D. C.spa
dc.creatorAcosta Ampudia, Yeny Yasbleidyspa
dc.creatorOjeda, E. C.spa
dc.creatorRodríguez, Y.spa
dc.creatorMonsalve Carmona, Diana Marcelaspa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorVega, D. A.spa
dc.creatorPaipilla, D.spa
dc.creatorTorres, L.spa
dc.creatorMolano González, Nicolásspa
dc.creatorOsorio, J. E.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:07:32Z
dc.date.available2020-05-26T00:07:32Z
dc.date.created2018spa
dc.description.abstractBackground and purpose: Zika virus (ZIKV) infection has been associated with an increased incidence of Guillain?Barré syndrome (GBS) but the relative frequency of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and axonal GBS subtypes is controversial. Methods: Twenty GBS patients diagnosed according to the Brighton criteria during the ZIKV outbreak in Cúcuta, Colombia, were evaluated clinically and electrophysiologically. The electrodiagnosis of GBS subtypes was made according to a recently described criteria set that demonstrated a high diagnostic accuracy on the basis of a single test. The electrophysiological features of 34 Italian AIDP patients were used as control. Results: All patients had symptoms compatible with ZIKV infection before the onset of GBS and ZIKV infection was laboratory confirmed through a plaque reduction neutralization test (PRNT90) in 100% of patients. The median time from onset of ZIKV infection symptoms to GBS was 5 days (interquartile range 1–6 days). Cranial nerve palsy was present in 85% of patients (facial palsy in 75%, bulbar nerve involvement in 60%), autonomic dysfunction in 85%, and 50% of patients required invasive mechanical ventilation. AIDP was diagnosed in 70% of patients. 40% of nerves of AIDP patients showed a prevalent distal demyelinating involvement but this pattern was not different from the Italian AIDP patients without ZIKV infection. Conclusions: Guillain?Barré syndrome associated with ZIKV infection in Cúcuta is characterized by a high frequency of cranial nerve involvement, autonomic dysfunction and requirement of mechanical ventilation indicating an aggressive and severe course. AIDP is the most frequent electrophysiological subtype. Demyelination is prevalent distally but this pattern is not specific for ZIKV infection.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/ene.13552
dc.identifier.issn14681331
dc.identifier.issn13515101
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24010
dc.language.isoengspa
dc.publisherBlackwell Publishing Ltdspa
dc.relation.citationEndPage650
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage644
dc.relation.citationTitleEuropean Journal of Neurology
dc.relation.citationVolumeVol. 25
dc.relation.ispartofEuropean Journal of Neurology, ISSN:14681331, 13515101, Vol.25, No.4 (2018); pp. 644-650spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85041564095&doi=10.1111%2fene.13552&partnerID=40&md5=cbe6251ee9424e499adfb20b38353898spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordImmunoglobulinspa
dc.subject.keywordAcute motor axonal neuropathyspa
dc.subject.keywordartificialeng
dc.subject.keywordAdultspa
dc.subject.keywordArthralgiaspa
dc.subject.keywordArticlespa
dc.subject.keywordArtificial ventilationspa
dc.subject.keywordAutonomic dysfunctionspa
dc.subject.keywordBrain electrophysiologyspa
dc.subject.keywordClinical articlespa
dc.subject.keywordClinical featurespa
dc.subject.keywordColombiaspa
dc.subject.keywordConjunctivitisspa
dc.subject.keywordCranial nerve paralysisspa
dc.subject.keywordDemyelinationspa
dc.subject.keywordDisease associationspa
dc.subject.keywordElectrodiagnosisspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordFemalespa
dc.subject.keywordFeverspa
dc.subject.keywordGuillain barre syndromespa
dc.subject.keywordHumanspa
dc.subject.keywordMalespa
dc.subject.keywordMotor nerve conductionspa
dc.subject.keywordMuscle action potentialspa
dc.subject.keywordNerve conductionspa
dc.subject.keywordNeurologic diseasespa
dc.subject.keywordPlasmapheresisspa
dc.subject.keywordPolyradiculoneuropathyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRashspa
dc.subject.keywordSerodiagnosisspa
dc.subject.keywordZika feverspa
dc.subject.keywordAutonomic neuropathyspa
dc.subject.keywordComplicationspa
dc.subject.keywordCranial neuropathyspa
dc.subject.keywordGuillain barre syndromespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordParalysisspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordViral plaque assayspa
dc.subject.keywordZika feverspa
dc.subject.keywordZika virusspa
dc.subject.keywordAdultspa
dc.subject.keywordAutonomic nervous system diseasesspa
dc.subject.keywordColombiaspa
dc.subject.keywordCranial nerve diseasesspa
dc.subject.keywordElectrodiagnosisspa
dc.subject.keywordFemalespa
dc.subject.keywordGuillain-barre syndromespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordNeural conductionspa
dc.subject.keywordParalysisspa
dc.subject.keywordRespirationeng
dc.subject.keywordViral plaque assayspa
dc.subject.keywordZika virusspa
dc.subject.keywordZika virus infectionspa
dc.subject.keywordAcute inflammatory demyelinating polyneuropathyspa
dc.subject.keywordClinical featuresspa
dc.subject.keywordElectrodiagnosisspa
dc.subject.keywordGuillain?barré syndromespa
dc.subject.keywordZika virusspa
dc.titleClinical and nerve conduction features in Guillain? Barré syndrome associated with Zika virus infection in Cúcuta, Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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