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Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia
| dc.creator | Rodríguez?Peña, Yolima | spa |
| dc.creator | Ibáñez Pinilla, Milcíades | spa |
| dc.date.accessioned | 2020-06-11T13:21:03Z | |
| dc.date.available | 2020-06-11T13:21:03Z | |
| dc.date.created | 2020-04-13 | spa |
| dc.description.abstract | OBJECTIVE: To establish the association between increased levels of D-dimer and severity of pre-eclampsia.METHODS: A nested, prospective cohort, analytical case-control study was conducted among women with pre-eclampsia between March 2017 and March 2018. Inclusion criteria were age over 18 years, gestational age of more than 20 weeks, a single pregnancy with a living fetus, and a diagnosis of pre-eclampsia. D-dimer was measured by immunoturbidimetry at the time of diagnosis of pre-eclampsia, applying cut-off points adjusted for gestational age. Statistical analysis involved unconditional logistic regression for the association of elevated D-dimer with severe pre-eclampsia adjusted by confusion variables.RESULTS: There were 132 patients with pre-eclampsia, of which 44 were classed as controls and 88 were classed as having severe pre-eclampsia (case group). Cohort characteristics included: age between 18 and 45 years (mean 28.0 ± 6.3 years); presence of gestational hypertension (10.6%), chronic arterial hypertension (9.0%); and gestational diabetes (5.3%). In the case group, levels of D-dimer were significantly higher than in controls (19.3% vs 2.3%, odds ratio [OR] 10.30, 95% confidence interval [CI] 1.32-80.14, P=0.004) as well as significant in the unconditional logistic regression model adjusted for maternal age, parity, gestational age, and comorbidities (OR 10.02, 95% CI 1.28-78.68, P=0.028).CONCLUSION: Elevated levels of D-dimer and severe pre-eclampsia are strongly associated, reinforcing evidence that one of the physiopathologic bases of the condition is the activation of fibrinolysis and the coagulation system. | eng |
| dc.format.mimetype | application/pdf | |
| dc.identifier.doi | https://doi.org/10.1002/ijgo.13163 | |
| dc.identifier.uri | https://repository.urosario.edu.co/handle/10336/24701 | |
| dc.language.iso | eng | |
| dc.publisher | International Journal of Gynecology & Obstetrics | spa |
| dc.relation.citationTitle | International Journal of Gynecology & Obstetrics | |
| dc.relation.ispartof | International Journal of Gynecology & Obstetrics, ISSN: , Vol., No. (2020-04-13); pp. | spa |
| dc.relation.uri | https://app.dimensions.ai/details/publication/pub.1126634103 | spa |
| dc.rights.accesRights | info:eu-repo/semantics/closedAccess | |
| dc.rights.acceso | Bloqueado (Texto referencial) | spa |
| dc.source.instname | instname:Universidad del Rosario | spa |
| dc.source.reponame | reponame:Repositorio Institucional EdocUR | spa |
| dc.subject.keyword | Medical and Health Sciences | spa |
| dc.subject.keyword | Paediatrics and Reproductive Medicine | spa |
| dc.title | Elevated levels of D?dimer tested by immunoturbidimetry are associated with the extent of severity of pre?eclampsia | spa |
| dc.type | article | eng |
| dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | |
| dc.type.spa | Artículo | spa |
