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Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army

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dc.creatorPatino, Luz H.
dc.creatorMéndez-Sarmiento, Claudia
dc.creatorRodriguez, Omaira
dc.creatorRomero, Yanira
dc.creatorVelandia, Daniel
dc.creatorAlvarado, Maria
dc.creatorPérez, Julie
dc.creatorDuque, Maria Clara
dc.creatorRamírez, Juan
dc.creator.googlePatino, Luz H.spa
dc.creator.googleMendez, Claudiaspa
dc.creator.googleRodriguez, Omairaspa
dc.creator.googleRomero, Yaniraspa
dc.creator.googleVelandia, Danielspa
dc.creator.googleAlvarado, Mariaspa
dc.creator.googlePérez, Juliespa
dc.creator.googleDuque, Maria Claraspa
dc.creator.googleRamírez, Juan Davidspa
dc.date.accessioned2018-11-29T17:07:49Z
dc.date.available2018-11-29T17:07:49Z
dc.date.created2017
dc.date.issued2017
dc.description.abstractIn Colombia, the cutaneous leishmaniasis (CL) is the most common manifestation across the army personnel. Hence, it is mandatory to determine the species associated with the disease as well as the association with the clinical traits. A total of 273 samples of male patients with CL were included in the study and clinical data of the patients was studied. PCR and sequencing analyses (Cytb and HSP70 genes) was performed to identify the species and the intra-specific genetic variability. A georeferenced database was constructed to identify the spatial distribution of Leishmania species isolated. The identification of five species of Leishmania that circulate in the areas where army personnel are deployed is described. Predominant infecting Leishmania species corresponds to L. braziliensis (61.1%), followed by Leishmania panamensis (33.5%), with a high distribution of both species at geographical and municipal level. The species L. guyanensis, L. mexicana and L. lainsoni were also detected at lower frequency. We also showed the identification of different genotypes within L. braziliensis and L. panamensis. In conclusion, we identified the Leishmania species circulating in the areas where Colombian army personnel are deployed, as well as the high intra-specific genetic variability of L. braziliensis and L. panamensis and how these genotypes are distributed at the geographic level. © 2017 Patino et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0005876
dc.identifier.issnISSN 1935-2727
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18758
dc.language.isoengspa
dc.relation.citationIssueNo. 8
dc.relation.citationTitlePLoS Neglected Tropical Diseases
dc.relation.citationVolumeVol. 11
dc.relation.ispartofPLoS Neglected Tropical Diseases, ISSN: 1935-2727, Vol. 11/No. 8 (2017)spa
dc.relation.urihttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0005876&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/spa
dc.source.bibliographicCitationMurray, H.W., Berman, J.D., Davies, C.R., Saravia, N.G., Advances in leishmaniasis (2005) Lancet, 366 (9496), pp. 1561-1577. , 1625734spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectProtozoariospa
dc.subjectCutáneospa
dc.subjectExtracción de ADNspa
dc.subjectVariabilidad genéticaspa
dc.subjectGenotipospa
dc.subjectHaplotipospa
dc.subjectHumanospa
dc.subjectPicadura de insectospa
dc.subjectLeishmania brasilensisspa
dc.subjectLeishmania guyanensisspa
dc.subjectLeishmania panamensisspa
dc.subjectEstudio clínico principalspa
dc.subjectSeguridad del pacientespa
dc.subjectÁrbol filogenéticospa
dc.subjectFilogeniaspa
dc.subjectReacción en cadena de la polimerasaspa
dc.subjectAnálisis de secuenciaspa
dc.subjectBiopsia de pielspa
dc.subjectLeishmaniosis cutáneaspa
dc.subjectSecuencia de ADNspa
dc.subjectAislamiento y Purificaciónspa
dc.subjectADN protozoariospa
dc.subjectPersonal militarspa
dc.subjectReacción en cadena de la polimerasaspa
dc.subject.keywordProtozoal Dnaspa
dc.subject.keywordMilitary Personneleng
dc.subject.keywordDNAeng
dc.subject.keywordSkin Leishmaniasisspa
dc.subject.keywordPolymerase Chain Reactionspa
dc.subject.keywordHumansspa
dc.subject.keywordSequence Analysiseng
dc.subject.keywordTopographyeng
dc.subject.keywordSkin Biopsyeng
dc.subject.keywordSequence Analysiseng
dc.subject.keywordPhylogenetic Treeeng
dc.subject.keywordProtozoaneng
dc.subject.keywordGenotypeeng
dc.subject.keywordCutaneouseng
dc.subject.keywordGenetic Variabilityeng
dc.subject.keywordDNA Extractioneng
dc.subject.keywordHaplotypeeng
dc.subject.keywordInsect Biteeng
dc.subject.keywordLeishmania Braziliensiseng
dc.subject.keywordLeishmania Guyanensiseng
dc.subject.keywordLeishmania Panamensiseng
dc.subject.keywordMajor Clinical Studyeng
dc.subject.keywordPhylogenyeng
dc.subject.keywordPatient Safetyeng
dc.subject.keywordDna Sequenceeng
dc.subject.keywordIsolation And Purificationeng
dc.titleSpatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian armyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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