Ítem
Acceso Abierto

The impact of HIV-1 within-host evolution on transmission dynamics

Mostrar el registro sencillo de la publicación
dc.creatorTheys, Kristofspa
dc.creatorLibin, Pieterspa
dc.creatorPineda-Peña, Andrea-Clemenciaspa
dc.creatorNowé, Annspa
dc.creatorVandamme, Anne-Miekespa
dc.creatorAbecasis, Ana Bspa
dc.date.accessioned2020-05-26T00:05:47Z
dc.date.available2020-05-26T00:05:47Z
dc.date.created2018spa
dc.description.abstractThe adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at within-host and between-host levels, and preferential transmission of ancestral donor viruses. Understanding the impact of within-host evolution for epidemiological studies is essential for the design of preventive and therapeutic measures. Herein, we review recent theoretical and experimental work that generated new insights into the complex link between within-host evolution and between-host fitness, revealing temporal and selective processes underlying the structure and dynamics of HIV-1 transmission. © 2017 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.coviro.2017.12.001
dc.identifier.issn18796257
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23826
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage101
dc.relation.citationStartPage92
dc.relation.citationTitleCurrent Opinion in Virology
dc.relation.citationVolumeVol. 28
dc.relation.ispartofCurrent Opinion in Virology, ISSN:18796257, Vol.28,(2018); pp. 92-101spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85038847406&doi=10.1016%2fj.coviro.2017.12.001&partnerID=40&md5=aa386338a1012c818f8441177fe1bad4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordChemokine receptor CCR5spa
dc.subject.keywordMoleculareng
dc.subject.keywordBottleneck populationspa
dc.subject.keywordCD4 lymphocyte countspa
dc.subject.keywordDisease coursespa
dc.subject.keywordGenetic distancespa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHost pathogen interactionspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordMolecular evolutionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordViral geneticsspa
dc.subject.keywordVirus loadspa
dc.subject.keywordVirus morphologyspa
dc.subject.keywordVirus transmissionspa
dc.subject.keywordVirus virulencespa
dc.subject.keywordEpidemicspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHost pathogen interactionspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordMolecular evolutionspa
dc.subject.keywordPathogenicityspa
dc.subject.keywordTheoretical modelspa
dc.subject.keywordTransmissionspa
dc.subject.keywordVirulencespa
dc.subject.keywordEpidemicsspa
dc.subject.keywordEvolutioneng
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHIV-1spa
dc.subject.keywordHost-Pathogen Interactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordModelseng
dc.subject.keywordVirulencespa
dc.titleThe impact of HIV-1 within-host evolution on transmission dynamicsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
1-s2-0-S1879625717301372-main.pdf
Tamaño:
890.14 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos