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Prevalence of celiac disease in Latin America: A systematic review and meta-regression

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dc.creatorParra-Medina, Rafael
dc.creatorMolano González, Nicolás
dc.creatorRojas-Villarraga, Adriana
dc.creatorAgmon-Levin, Nancy
dc.creatorArango, Maria-Teresa
dc.creatorShoenfeld, Yehuda
dc.creatorAnaya, Juan-Manuel
dc.creator.googleParra-Medina, Rafaelspa
dc.creator.googleMolano-Gonzalez, Nicolásspa
dc.creator.googleRojas-Villarraga, Adrianaspa
dc.creator.googleAgmon-Levin, Nancyspa
dc.creator.googleArango, María-Teresaspa
dc.creator.googleShoenfeld, Yehudaspa
dc.creator.googleAnaya, Juan-Manuelspa
dc.date.accessioned2020-04-02T23:12:44Z
dc.date.available2020-04-02T23:12:44Z
dc.date.created2015-05-05
dc.date.issued2015
dc.description.abstractBackground: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis. Methods and Findings: This was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46%and 0.64%. The prevalence of CD in firstdegree relatives of CD probands was 5.5%. The coexistence of CD and type 1 diabetes mellitus varied from 4.6% to 8.7%, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies). Conclusions: Although CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans. © 2015 Parra-Medina et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0124040
dc.identifier.issn1932-6203
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21445
dc.language.isoengspa
dc.relation.citationIssueNo. 5
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 10
dc.relation.ispartofPLoS ONE, ISSN: 1932-6203 Vol. 10, No. 5 (2015)spa
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0124040&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectAnticuerpo endomisiospa
dc.subjectAnticuerpo de inmunoglobulina Aspa
dc.subjectAnticuerpo de inmunoglobulina Gspa
dc.subjectProteína glutamina gamma glutamiltransferasaspa
dc.subjectAnticuerpo autoanticuerpospa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordEndomysium antibodyspa
dc.subject.keywordImmunoglobulin A antibodyspa
dc.subject.keywordImmunoglobulin G antibodyspa
dc.subject.keywordProtein glutamine gamma glutamyltransferase antibodyspa
dc.subject.keywordAutoantibodyspa
dc.subject.lembEnfermedad celíacaspa
dc.subject.lembGlutenspa
dc.titlePrevalence of celiac disease in Latin America: A systematic review and meta-regressionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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