Ítem
Acceso Abierto

Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.

Mostrar el registro sencillo de la publicación
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorAmaya-Amaya, Jennyspa
dc.creatorRodriguez-Rodriguez, Albertospa
dc.creatorMantilla, Ruben Dspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-08-06T16:20:22Z
dc.date.available2020-08-06T16:20:22Z
dc.date.created2012spa
dc.description.abstractSimilar pathophysiological mechanisms within autoimmune diseases have stimulated searches for common genetic roots. Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. When three or more autoimmune diseases coexist, this condition is called multiple autoimmune syndrome (MAS). We analyzed the presence of polyautoimmunity in 1,083 patients belonging to four autoimmune disease cohorts. Polyautoimmunity was observed in 373 patients (34.4%). Autoimmune thyroid disease (AITD) and Sjogren's syndrome (SS) were the most frequent diseases encountered. Factors significantly associated with polyautoimmunity were female gender and familial autoimmunity. Through a systematic literature review, an updated search was done for all MAS cases (January 2006-September 2011). There were 142 articles retrieved corresponding to 226 cases. Next, we performed a clustering analysis in which AITD followed by systemic lupus erythematosus and SS were the most hierarchical diseases encountered. Our results indicate that coexistence of autoimmune diseases is not uncommon and follows a grouping pattern. Polyautoimmunity is the term proposed for this association of disorders, which encompasses the concept of a common origin for these diseases.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2012/254319
dc.identifier.issnISSN: 20900422
dc.identifier.issnEISSN: 2090-0430
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25976
dc.language.isoengspa
dc.publisherHindawi Publishing Corporationspa
dc.relation.citationEndPage319
dc.relation.citationStartPage254
dc.relation.citationTitleAutoimmune diseases
dc.relation.citationVolumeVol. 2012
dc.relation.ispartofAutoimmune diseases, ISSN: 20900422 ; EISSN: 2090-0430, Vol.2012 (2012); pp.254-319spa
dc.relation.urihttp://downloads.hindawi.com/journals/ad/2012/254319.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceAutoimmune diseasesspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordpathophysiological mechanismsspa
dc.subject.keywordPolyautoimmunityspa
dc.subject.keywordautoimmune diseasespa
dc.titleIntroducing polyautoimmunity: Secondary autoimmune diseases no longer exist.spa
dc.title.TranslatedTitleIntroducción de la poliautoinmunidad: las enfermedades autoinmunes secundarias ya no existen.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
254319.pdf
Tamaño:
1.3 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos