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The CCR5 delta 32 polymorphism (rs333) is not associated with Sjögren's syndrome or Type 1 Diabetes in Colombians

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dc.creatorMaier-Moore, Jacen S.
dc.creatorCañas, Carlos A.
dc.creatorTobón, Gabriel
dc.creatorArango, Alvaro
dc.creatorAnaya, Juan-Manuel
dc.creatorScofield, R. Hal
dc.date.accessioned2020-08-06T16:21:39Z
dc.date.available2020-08-06T16:21:39Z
dc.date.created2013-08-01
dc.description.abstractSjögren's syndrome (SS) and Type 1 Diabetes (T1D) are chronic, progressive autoimmune diseases that affect exocrine glands or ?-cells in the islets of Langerhans in the pancreas, respectively. Typical features of both diseases include production of antibodies against self-antigens and T and B cell infiltrates in organ-specific tissues [12] . Migration of pro-inflammatory memory T cells and monocytes into chronically inflamed tissues is driven by Th1-related chemokines and their receptors. This includes CCR5, a seven-transmembrane domain G protein-coupled receptor (GPCR) involved in intracellular signaling [3] . In Sjögren's syndrome, mRNA and receptor expression of CCR5 are significantly upregulated in inflammatory Th1 cells, parotid gland excretory ducts and conjunctival epithelium of SS-affected individuals indicating that it has a significant role in the progression and severity of pSS disease [45] . In Type 1 Diabetes, recruitment of activated CCR5-expressing T cells to the pancreas or kidney can promote renal disease and impairment of insulin production [6] .eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.clim.2013.05.010
dc.identifier.issnISSN: 1521-7035
dc.identifier.issnEISSN: 1521-6616
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26418
dc.language.isoeng
dc.publisherElsevier
dc.relation.citationEndPage208
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage206
dc.relation.citationTitleClinical Immunology
dc.relation.citationVolumeVol. 148
dc.relation.ispartofClinical Immunology, ISSN:1521-7035 ; EISSN:1521-6616, Vol.148, No.2 (August, 2013); pp.206-208
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S1521661613001307?via%3Dihub
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordChemokine receptor CCR5spa
dc.subject.keywordDNAspa
dc.subject.keywordCell migrationspa
dc.subject.keywordCell surfacespa
dc.subject.keywordColombiaspa
dc.subject.keywordDNA polymorphismspa
dc.subject.keywordFrameshift mutationspa
dc.subject.keywordGene deletionspa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordLetterspa
dc.subject.keywordLeukocytespa
dc.subject.keywordPriority journalspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordCCR5 delta 32spa
dc.subject.keywordRs333spa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordType 1 Diabetesspa
dc.subject.keywordColombiaspa
dc.subject.keywordDiabetes Mellitus Type 1spa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordPolymorphism Geneticspa
dc.subject.keywordReceptors CCR5spa
dc.subject.keywordSjogren's Syndromespa
dc.subject.keywordCCR5 delta 32spa
dc.subject.keywordRs333spa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordType 1 Diabetesspa
dc.titleThe CCR5 delta 32 polymorphism (rs333) is not associated with Sjögren's syndrome or Type 1 Diabetes in Colombiansspa
dc.title.TranslatedTitleEl polimorfismo CCR5 delta 32 (rs333) no está asociado con el síndrome de Sjögren o la diabetes tipo 1 en colombianosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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