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Measurement of neurovascular coupling in neonates

dc.creatorHendrikx, Driesspa
dc.creatorSmits, Annespa
dc.creatorLavanga, Mariospa
dc.creatorDe Wel, Ofeliespa
dc.creatorThewissen, Liesbethspa
dc.creatorJansen, Katrienspa
dc.creatorCaicedo Dorado, Alexander
dc.creatorVan Huffel, Sabinespa
dc.creatorNaulaers, Gunnarspa
dc.date.accessioned2020-05-26T00:08:36Z
dc.date.available2020-05-26T00:08:36Z
dc.date.created2019spa
dc.description.abstractNeurovascular coupling refers to the mechanism that links the transient neural activity to the subsequent change in cerebral blood flow, which is regulated by both chemical signals and mechanical effects. Recent studies suggest that neurovascular coupling in neonates and preterm born infants is different compared to adults. The hemodynamic response after a stimulus is later and less pronounced and the stimulus might even result in a negative (hypoxic) signal. In addition, studies both in animals and neonates confirm the presence of a short hypoxic period after a stimulus in preterm infants. In clinical practice, different methodologies exist to study neurovascular coupling. The combination of functional magnetic resonance imaging or functional near-infrared spectroscopy (brain hemodynamics) with EEG (brain function) is most commonly used in neonates. Especially near-infrared spectroscopy is of interest, since it is a non-invasive method that can be integrated easily in clinical care and is able to provide results concerning longer periods of time. Therefore, near-infrared spectroscopy can be used to develop a continuous non-invasive measurement system, that could be used to study neonates in different clinical settings, or neonates with different pathologies. The main challenge for the development of a continuous marker for neurovascular coupling is how the coupling between the signals can be described. In practice, a wide range of signal interaction measures exist. Moreover, biomedical signals often operate on different time scales. In a more general setting, other variables also have to be taken into account, such as oxygen saturation, carbon dioxide and blood pressure in order to describe neurovascular coupling in a concise manner. Recently, new mathematical techniques were developed to give an answer to these questions. This review discusses these recent developments. © 2019 Hendrikx, Smits, Lavanga, De Wel, Thewissen, Jansen, Caicedo, Van Huffel and Naulaers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fphys.2019.00065
dc.identifier.issn1664042X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24098
dc.language.isoengspa
dc.publisherFrontiers Media S.A.spa
dc.relation.citationIssueNo. FEB
dc.relation.citationTitleFrontiers in Physiology
dc.relation.citationVolumeVol. 10
dc.relation.ispartofFrontiers in Physiology, ISSN:1664042X, Vol.10, No.FEB (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85065912268&doi=10.3389%2ffphys.2019.00065&partnerID=40&md5=c479d09c98261e1da9df6d02ffff31e0spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBrain functionspa
dc.subject.keywordElectroencephalogramspa
dc.subject.keywordFunctional connectivityspa
dc.subject.keywordFunctional magnetic resonance imagingspa
dc.subject.keywordFunctional neuroimagingspa
dc.subject.keywordGraph theoryspa
dc.subject.keywordHemodynamicsspa
dc.subject.keywordHumanspa
dc.subject.keywordNear infrared spectroscopyspa
dc.subject.keywordNeurophysiologyspa
dc.subject.keywordNeurovascular couplingspa
dc.subject.keywordNewbornspa
dc.subject.keywordNonhumanspa
dc.subject.keywordReviewspa
dc.subject.keywordSpatiotemporal analysisspa
dc.subject.keywordTheoryspa
dc.subject.keywordCerebral blood flowspa
dc.subject.keywordEegspa
dc.subject.keywordGraph theoryspa
dc.subject.keywordNeonatesspa
dc.subject.keywordNeurovascular couplingspa
dc.subject.keywordNirsspa
dc.titleMeasurement of neurovascular coupling in neonatesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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