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Interplay between Developmental Flexibility and Determinism in the Evolution of Mimetic Heliconius Wing Patterns

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dc.creatorConcha C.spa
dc.creatorWallbank R.W.R.spa
dc.creatorHanly J.J.spa
dc.creatorFenner J.spa
dc.creatorLivraghi L.spa
dc.creatorRivera E.S.spa
dc.creatorPaulo D.F.spa
dc.creatorArias C.spa
dc.creatorVargas M.spa
dc.creatorSanjeev M.spa
dc.creatorMorrison C.spa
dc.creatorTian D.spa
dc.creatorAguirre P.spa
dc.creatorFerrara S.spa
dc.creatorFoley J.spa
dc.creatorPardo Díaz, Geimy Carolinaspa
dc.creatorSalazar, Camilospa
dc.creatorLinares, Mauriciospa
dc.creatorMassardo D.spa
dc.creatorCounterman B.A.spa
dc.creatorScott M.J.spa
dc.creatorJiggins C.D.spa
dc.creatorPapa R.spa
dc.creatorMartin A.spa
dc.creatorMcMillan W.O.spa
dc.date.accessioned2020-05-26T00:05:29Z
dc.date.available2020-05-26T00:05:29Z
dc.date.created2019spa
dc.description.abstractTo what extent can we predict how evolution occurs? Do genetic architectures and developmental processes canalize the evolution of similar outcomes in a predictable manner? Or do historical contingencies impose alternative pathways to answer the same challenge? Examples of Müllerian mimicry between distantly related butterfly species provide natural replicates of evolution, allowing us to test whether identical wing patterns followed parallel or novel trajectories. Here, we explore the role that the signaling ligand WntA plays in generating mimetic wing patterns in Heliconius butterflies, a group with extraordinary mimicry-related wing pattern diversity. The radiation is relatively young, and numerous cases of wing pattern mimicry have evolved within the last 2.5–4.5 Ma. WntA is an important target of natural selection and is one of four major effect loci that underlie much of the pattern variation in the group. We used CRISPR/Cas9 targeted mutagenesis to generate WntA-deficient wings in 12 species and a further 10 intraspecific variants, including three co-mimetic pairs. In all tested butterflies, WntA knockouts affect pattern broadly and cause a shift among every possible scale cell type. Interestingly, the co-mimics lacking WntA were very different, suggesting that the gene networks that pattern a wing have diverged considerably among different lineages. Thus, although natural selection channeled phenotypic convergence, divergent developmental contexts between the two major Heliconius lineages opened different developmental routes to evolve resemblance. Consequently, even under very deterministic evolutionary scenarios, our results underscore a surprising unpredictability in the developmental paths underlying convergence in a recent radiation. © 2019 Elsevier LtdConcha et al. use CRISPR/Cas9 genome editing to knock out a major wing patterning gene, WntA, in mimetic species of Heliconius butterflies and report that WntA is used in divergent gene regulatory networks in co-mimics and that resemblance is achieved through differential expression of WntA and its interaction with the specific genetic background. © 2019 Elsevier Ltdeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.cub.2019.10.010
dc.identifier.issn9609822
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23799
dc.language.isoengspa
dc.publisherCell Pressspa
dc.relation.citationEndPage4009.e4
dc.relation.citationIssueNo. 23
dc.relation.citationStartPage3996
dc.relation.citationTitleCurrent Biology
dc.relation.citationVolumeVol. 29
dc.relation.ispartofCurrent Biology, ISSN:9609822, Vol.29, No.23 (2019); pp. 3996-4009.e4spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85075449549&doi=10.1016%2fj.cub.2019.10.010&partnerID=40&md5=7a669358537527a3745bcf5c9be5b829spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordArticlespa
dc.subject.keywordButterflyspa
dc.subject.keywordConvergent evolutionspa
dc.subject.keywordCrispr-cas9 systemspa
dc.subject.keywordKnockout genespa
dc.subject.keywordMullerian mimicryspa
dc.subject.keywordNatural selectionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordSite directed mutagenesisspa
dc.subject.keywordWingspa
dc.subject.keywordWnt signalingspa
dc.subject.keywordButterfly wing patternsspa
dc.subject.keywordColor patternsspa
dc.subject.keywordConvergent evolutionspa
dc.subject.keywordCrispr mutagenesisspa
dc.subject.keywordHeliconius butterfliesspa
dc.subject.keywordMüllerian mimicryspa
dc.subject.keywordWnt signalingspa
dc.subject.keywordWntaspa
dc.titleInterplay between Developmental Flexibility and Determinism in the Evolution of Mimetic Heliconius Wing Patternsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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