Ítem
Acceso Abierto

Genetic diversity and selection in three plasmodium vivax merozoite surface protein 7 (pvmsp-7) genes in a colombian population

Mostrar el registro sencillo de la publicación
dc.audienceComunidad Rosaristaspa
dc.creatorGarzón Ospina, Diego
dc.creatorLopez, Carolina
dc.creatorForero Rodriguez, Johanna
dc.creatorPatarroyo, Manuel A.
dc.creator.googleGarzon Ospina, Diego
dc.creator.googleLopez, Carolina
dc.creator.googleForero Rodriguez, Johanna
dc.creator.googlePatarroyo, Manuel A.
dc.date.accessioned2014-08-13T16:26:14Z
dc.date.available2014-08-13T16:26:14Z
dc.date.created2012-09-25
dc.date.issued2012
dc.description.abstractA completely effective vaccine for malaria (one of the major infectious diseases worldwide) is not yet available; different membrane proteins involved in parasite-host interactions have been proposed as candidates for designing it. It has been found that proteins encoded by the merozoite surface protein (msp)-7 multigene family are antibody targets in natural infection; the nucleotide diversity of three Pvmsp-7 genes was thus analyzed in a Colombian parasite population. By contrast with P. falciparum msp-7 loci and ancestral P. vivax msp-7 genes, specie-specific duplicates of the latter specie display high genetic variability, generated by single nucleotide polymorphisms, repeat regions, and recombination. At least three major allele types are present in Pvmsp-7C, Pvmsp-7H and Pvmsp-7I and positive selection seems to be operating on the central region of these msp-7 genes. Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0045962
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8831
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 9
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 7
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 7 N. 9 Sep. 25, 2012spa
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045962
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcEnfermedades
dc.subject.decsMalariaspa
dc.subject.decsGenomaspa
dc.subject.decsEnfermedades infecciosasspa
dc.subject.decsGenéticaspa
dc.subject.keywordCaenorhabitis- elegans genomeeng
dc.subject.keywordAmino-acid siteseng
dc.subject.keywordMalaria parasiteeng
dc.subject.keywordPositive selectioneng
dc.subject.keywordIntragenic recombinationeng
dc.subject.keywordStatistical testseng
dc.subject.keywordDeath evolutioneng
dc.subject.keywordMSP7 familyeng
dc.subject.keywordFalciparumeng
dc.subject.keywordComplexeng
dc.titleGenetic diversity and selection in three plasmodium vivax merozoite surface protein 7 (pvmsp-7) genes in a colombian populationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Genetic.pdf
Tamaño:
514.22 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos