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Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region

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dc.creatorCastellsagué, Xavier
dc.creatorAult, Kevin A.
dc.creatorBosch, F. Xavier
dc.creatorBrown, Darron
dc.creatorCuzick, Jack
dc.creatorFerris, Daron G.
dc.creatorJoura, Elmar A.
dc.creatorGarland, Suzanne M.
dc.creatorGiuliano, Anna R
dc.creatorHernandez-Avila, Mauricio
dc.creatorHuh, Warner
dc.creatorIversen, Ole-Erik
dc.creatorKjaer, Susanne K.
dc.creatorLuna, Joaquin
dc.creatorMonsonego, Joseph
dc.creatorMuñoz, Nubia
dc.creatorMyers, Evan
dc.creatorPaavonen, Jorma
dc.creatorPitisuttihum, Punnee
dc.creatorSteben, Marc
dc.creatorWheeler, Cosette M.
dc.creatorPerez, Gonzalo
dc.creatorSaah, Alfred
dc.creatorPitisuttihum, Punnee
dc.creatorSteben, Marc
dc.creatorWheeler, Cosette M.
dc.creatorPerez, Gonzalo
dc.creatorSaah, Alfred
dc.creatorLuxembourg, Alain
dc.creatorSings, Heather L
dc.creatorVelicer, Christine
dc.creator.googleCastellsagué, Xavierspa
dc.creator.googleAult, Kevin A.spa
dc.creator.googleBosch, F. Xavierspa
dc.creator.googleBrown, Darronspa
dc.creator.googleCuzick, Jackspa
dc.creator.googleFerris, Daron G.spa
dc.creator.googleJoura, Elmar A.spa
dc.creator.googleGarland, Suzanne M.spa
dc.creator.googleGiuliano, Anna Rspa
dc.creator.googleHernandez-Avila, Mauriciospa
dc.creator.googleHuh, Warnerspa
dc.creator.googleIversen, Ole-Erikspa
dc.creator.googleKjaer, Susanne K.spa
dc.creator.googleLuna, Joaquinspa
dc.creator.googleMonsonego, Josephspa
dc.creator.googleMuñoz, Nubiaspa
dc.creator.googleMyers, Evanspa
dc.creator.googlePaavonen, Jormaspa
dc.creator.googlePitisuttihum, Punneespa
dc.creator.googleSteben, Marcspa
dc.creator.googleWheeler, Cosette M.spa
dc.creator.googlePerez, Gonzalospa
dc.creator.googleSaah, Alfredspa
dc.creator.googlePitisuttihum, Punneespa
dc.creator.googleSteben, Marcspa
dc.creator.googleWheeler, Cosette M.spa
dc.creator.googlePerez, Gonzalospa
dc.creator.googleSaah, Alfredspa
dc.creator.googleLuxembourg, Alainspa
dc.creator.googleSings, Heather Lspa
dc.creator.googleVelicer, Christinespa
dc.date.accessioned2019-01-22T16:23:31Z
dc.date.available2019-01-22T16:23:31Z
dc.date.created2016
dc.date.issued2016
dc.descriptionBackground: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. © 2016 The Authors.spa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.pvr.2016.03.002
dc.identifier.issnISSN 2405-8521
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18903
dc.language.isoengspa
dc.relation.citationEndPage69
dc.relation.citationStartPage61
dc.relation.citationTitlePapillomavirus Research
dc.relation.citationVolumeVol. 2
dc.relation.ispartofPapillomavirus Research, ISSN: 2405-8521, Vol. 2 (2016) pp. 61-69spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2405852116000045spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.source.bibliographicCitationJoura, E.A., Giuliano, A.R., Iversen, O.E., Bouchard, C., Mao, C., Mehlsen, J., A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women (2015) N. Engl. J. Med., 372, pp. 711-723spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectHuman papillomavirusspa
dc.subjectCervical cancerspa
dc.subjectCervical intraepithelial neoplasiaspa
dc.subjectAdenocarcinoma in situspa
dc.subject.ddcEnfermedadesspa
dc.subject.decsWart Virus Vaccinespa
dc.subject.decsAdenocarcinoma In Situspa
dc.subject.decsAge Distributionspa
dc.subject.decsArticlespa
dc.subject.decsCondyloma Acuminatumspa
dc.subject.decsGenotypespa
dc.subject.decsGeographic Distributionspa
dc.subject.decsHealth Programspa
dc.subject.decsHumanspa
dc.subject.decsHuman Papillomavirus Type 11spa
dc.subject.decsHuman Papillomavirus Type 16spa
dc.subject.decsHuman Papillomavirus Type 18spa
dc.subject.decsHuman Papillomavirus Type 31spa
dc.subject.decsHuman Papillomavirus Type 33spa
dc.subject.decsHuman Papillomavirus Type 45spa
dc.subject.decsHuman Papillomavirus Type 52spa
dc.subject.decsHuman Papillomavirus Type 58spa
dc.subject.decsHuman Papillomavirus Type 6spa
dc.subject.decsImmunizationspa
dc.subject.decsInfection Riskspa
dc.subject.decsMixed Infectionspa
dc.subject.decsMolecular Epidemiologyspa
dc.subject.decsNonhumanspa
dc.subject.decsPrevalencespa
dc.subject.decsPriority Journalspa
dc.subject.decsSystematic Reviewspa
dc.subject.decsUterine Cervix Carcinoma In Situspa
dc.subject.decsVirus Detectionspa
dc.subject.decsWart Virusspa
dc.subject.decsAdenocarcinomaspa
dc.subject.decsAdolescentspa
dc.subject.decsAdultspa
dc.subject.decsAsiaspa
dc.subject.decsClassificationspa
dc.subject.decsEuropespa
dc.subject.decsFemalespa
dc.subject.decsGeneticsspa
dc.subject.decsIsolation And Purificationspa
dc.subject.decsMiddle Agedspa
dc.subject.decsNorth Americaspa
dc.subject.decsPapillomaviridaespa
dc.subject.decsRandomized Controlled Trial (Topic)spa
dc.subject.decsSouth And Central Americaspa
dc.subject.decsUterine Cervix Carcinoma In Situspa
dc.subject.decsVirologyspa
dc.subject.decsYoung Adultspa
dc.subject.decsAdenocarcinomaspa
dc.subject.decsAdolescentspa
dc.subject.decsAdultspa
dc.subject.decsAsiaspa
dc.subject.decsCervical Intraepithelial Neoplasiaspa
dc.subject.decsEuropespa
dc.subject.decsFemalespa
dc.subject.decsGenotypespa
dc.subject.decsHumansspa
dc.subject.decsLatin Americaspa
dc.subject.decsMiddle Agedspa
dc.subject.decsNorth Americaspa
dc.subject.decsPapillomaviridaespa
dc.subject.decsRandomized Controlled Trials As Topicspa
dc.subject.decsYoung Adultspa
dc.subject.lembPapilomaspa
dc.subject.lembNeoplasmasspa
dc.subject.lembAdenocarcinoma in Situspa
dc.titleHuman papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by regionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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