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Limited genetic polymorphism of the Plasmodium vivax low molecular weight rhoptry protein complex in the Colombian population

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dc.creatorGarzon-Ospina, Diegospa
dc.creatorRomero-Murillo, Lizaspa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-26T00:11:17Z
dc.date.available2020-05-26T00:11:17Z
dc.date.created2010spa
dc.description.abstractProteins involved in parasite adhesion and invasion are considered the best candidates for the development of asexual blood-stage antimalarial vaccines. Such vaccine candidates should be accessible by the immune system and have limited diversity. Considering the promising results obtained in previous trials by immunizing monkeys with the rhoptry-associated proteins 1 and 2 (RAP-1 and RAP-2), here we assessed the genetic variability of the Plasmodium vivax rap-1 and rap-2 genes isolated from Colombian parasite populations. Limited sequence diversity was found in these genes, possibly as a result of a functional/structural restriction. The presence of several haplotypes at relatively low frequencies and the excess of singleton mutations suggests that a demographic process might be affecting the loci. Our results support the inclusion of PvRAP-1 and PvRAP-2 in the design of an antimalarial subunit-based vaccine against P. vivax, which would avoid inducing allele-specific immunity. © 2009 Elsevier B.V. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.meegid.2009.12.004
dc.identifier.issn15671348
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24293
dc.language.isoengspa
dc.relation.citationEndPage267
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage261
dc.relation.citationTitleInfection, Genetics and Evolution
dc.relation.citationVolumeVol. 10
dc.relation.ispartofInfection, Genetics and Evolution, ISSN:15671348, Vol.10, No.2 (2010); pp. 261-267spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-76849090794&doi=10.1016%2fj.meegid.2009.12.004&partnerID=40&md5=761100acfa3ee8a809df41f1666865dbspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordProteinspa
dc.subject.keywordvivaxeng
dc.subject.keywordRhoptry associated protein 2spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordArticlespa
dc.subject.keywordDna sequencespa
dc.subject.keywordExonspa
dc.subject.keywordGene linkage disequilibriumspa
dc.subject.keywordGene locusspa
dc.subject.keywordGene mutationspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic recombinationspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHaplotypespa
dc.subject.keywordHumanspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordParasite isolationspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSequence alignmentspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordColombiaspa
dc.subject.keywordEvolutioneng
dc.subject.keywordGeographyspa
dc.subject.keywordHumansspa
dc.subject.keywordLinkage disequilibriumspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMalariaeng
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordSequence alignmentspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordDemographic processspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordMalaria vaccine candidatesspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordRhoptry-associated protein 1spa
dc.subject.keywordRhoptry-associated protein 2spa
dc.titleLimited genetic polymorphism of the Plasmodium vivax low molecular weight rhoptry protein complex in the Colombian populationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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