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Identification and characterisation of the Plasmodium vivax rhoptry-associated protein 2

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dc.creatorPerez-Leal, Oscarspa
dc.creatorLopez, Yolandaspa
dc.creatorCortes, Jimenaspa
dc.creatorRojas-Caraballo, Josespa
dc.creatorGomez, Andromedaspa
dc.creatorMoncada, Camilospa
dc.creatorRosas, Jaiverspa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-08-06T16:20:17Z
dc.date.available2020-08-06T16:20:17Z
dc.date.created2005-11-25spa
dc.description.abstractPlasmodium vivax is currently the most widespread of the four parasite species causing malaria in humans around the world. It causes more than 75 million clinical episodes per year, mainly on the Asian and American continents. Identifying new antigens to be further tested as anti-P. vivax vaccine candidates has been greatly hampered by the difficulty of maintaining this parasite cultured in vitro. Taking into account that one of the most promising vaccine candidates against Plasmodium falciparum is the rhoptry-associated protein 2, we have identified the P. falciparum rhoptry-associated protein 2 homologue in P. vivax in the present study. This protein has 400 residues, having an N-terminal 21 amino-acid stretch compatible with a signal peptide and, as occurs with its falciparum homologue, it lacks repeat sequences. The protein is expressed in asexual stage P. vivax parasites and polyclonal sera raised against this protein recognised a 46 kDa band in parasite lysate in a Western blot assay.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2005.09.120
dc.identifier.issnISSN: 0006-291X
dc.identifier.issnEISSN: 1090-2104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25943
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage337
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage319
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 315
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN: 0006-291X;EISSN: 1090-2104, Vol.315, No.2 (2005); pp.319-337spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0006291X05021509spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceBiochemical and Biophysical Research Communicationsspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordMalariaspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordRhoptry-associated protein 2spa
dc.subject.keywordVaccine candidatespa
dc.subject.keywordBioinformaticsspa
dc.titleIdentification and characterisation of the Plasmodium vivax rhoptry-associated protein 2spa
dc.title.TranslatedTitleIdentificación y caracterización de la proteína 2 asociada a la rhoptry de Plasmodium vivaxspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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