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Murine models susceptibility to distinct Trypanosoma cruzi i genotypes infection

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dc.creatorLeón C.M.spa
dc.creatorMontilla M.spa
dc.creatorVanegas R.spa
dc.creatorCastillo, Maríaspa
dc.creatorParra E.spa
dc.creatorRamírez, Juan Davidspa
dc.date.accessioned2020-05-25T23:57:52Z
dc.date.available2020-05-25T23:57:52Z
dc.date.created2017spa
dc.description.abstractChagas disease is a complex zoonosis that affects around 8 million people worldwide. This pathology is caused by Trypanosoma cruzi, a kinetoplastid parasite that shows tremendous genetic diversity evinced in six distinct Discrete Typing Units (TcI-TcVI) including a recent genotype named as TcBat and associated with anthropogenic bats. TcI presents a broad geographical distribution and has been associated with chronic cardiomyopathy. Recent phylogenetic studies suggest the existence of two genotypes (Domestic (TcIDom) and sylvatic TcI) within TcI. The understanding of the course of the infection in different mouse models by these two genotypes is not yet known. Therefore, we infected 126 animals (ICR-CD1, National Institute of Health (NIH) and Balb/c) with two TcIDom strains and one sylvatic strain for a follow-up period of 60 days. We quantified the parasitaemia, immune response and histopathology observing that the maximum day of parasitaemia was achieved at day 21 post-infection. Domestic strains showed higher parasitaemia than the sylvatic strain in the three mouse models; however in the survival curves Balb/c mice were less susceptible to infection compared with NIH and ICR-CD1. Our results suggest that the genetic background plays a fundamental role in the natural history of the infection and the sympatric TcI genotypes have relevant implications in disease pathogenesis. © 2016 Cambridge University Press.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1017/S0031182016001980
dc.identifier.issn14698161
dc.identifier.issn00311820
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22758
dc.language.isoengspa
dc.publisherCambridge University Pressspa
dc.relation.citationEndPage519
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage512
dc.relation.citationTitleParasitology
dc.relation.citationVolumeVol. 144
dc.relation.ispartofParasitology, ISSN:14698161, 00311820, Vol.144, No.4 (2017); pp. 512-519spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84994552840&doi=10.1017%2fS0031182016001980&partnerID=40&md5=3aaf16071412dec300aa41c52978c6e5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordImmunoglobulin G antibodyspa
dc.subject.keywordT6 antigenspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordArticlespa
dc.subject.keywordCardiomyopathyspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordFollow upspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHistopathologyspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunofluorescence testspa
dc.subject.keywordInbred strainspa
dc.subject.keywordInoculationspa
dc.subject.keywordMalespa
dc.subject.keywordMousespa
dc.subject.keywordMurine modelspa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordSurvival ratespa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordAnimalspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordParasitologyspa
dc.subject.keywordAnimalsspa
dc.subject.keywordChagas Diseasespa
dc.subject.keywordDisease Susceptibilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordMicespa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordInbred linespa
dc.subject.keywordMicespa
dc.subject.keywordTrypanosoma cruzispa
dc.titleMurine models susceptibility to distinct Trypanosoma cruzi i genotypes infectionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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