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The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries

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dc.creatorMontes, Felix R.spa
dc.creatorCabrera, Marianaspa
dc.creatorDelgadillo, Alexandraspa
dc.creatorSalgar, Carlosspa
dc.creatorEcheverri, Dariospa
dc.date.accessioned2020-05-26T00:02:18Z
dc.date.available2020-05-26T00:02:18Z
dc.date.created2009spa
dc.description.abstractThere is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the involvement of potassium channels in this response. Segments of IMA were obtained from 29 patients who underwent coronary artery bypass graft surgery. They were cut into rings, suspended between two wire hooks in organ bath chambers and constricted submaximally with norepinephrine. Caffeine (3.16 × 10- 9 to 10- 4 mol/L) was added in a cumulative fashion to rings with or without functional endothelium and concentration response curves were constructed. The response to caffeine was also evaluated after incubation with adenosine 3?,5?-triphosphate (ATP)-dependent potassium channel blocker glibenclamide, voltage-dependent potassium channel blocker 4-aminopyridine and large-conductance calcium-activated potassium channel inhibitor tetraethylammonium. Caffeine produced a potent, concentration-dependent relaxation of IMA. The relaxant responses did not differ significantly between endothelium-intact and endothelium-denuded preparations. Incubation with different potassium channel inhibitors (glibenclamide, 4-aminopyridine and tetraethylammonium) did not cause significant alterations in the relaxant responses to caffeine. These results suggest that the vasodilatory response to caffeine in human IMA is independent of endothelial function and is not mediated by potassium channels. © 2008 Elsevier Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vph.2008.11.002
dc.identifier.issn15371891
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23470
dc.language.isoengspa
dc.relation.citationEndPage136
dc.relation.citationIssueNo. 43924
dc.relation.citationStartPage132
dc.relation.citationTitleVascular Pharmacology
dc.relation.citationVolumeVol. 50
dc.relation.ispartofVascular Pharmacology, ISSN:15371891, Vol.50, No.43924 (2009); pp. 132-136spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-58549102308&doi=10.1016%2fj.vph.2008.11.002&partnerID=40&md5=64ba0d0bea4da031b615f07b7da23ff6spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keyword4 aminopyridinespa
dc.subject.keyworddrugeng
dc.subject.keywordGlibenclamidespa
dc.subject.keywordNoradrenalinspa
dc.subject.keywordPotassium channelspa
dc.subject.keywordPotassium channel blocking agentspa
dc.subject.keywordTetrylammoniumspa
dc.subject.keywordArticlespa
dc.subject.keywordBathspa
dc.subject.keywordClinical articlespa
dc.subject.keywordConcentration (parameters)spa
dc.subject.keywordCoronary artery bypass surgeryspa
dc.subject.keywordEndotheliumspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman tissuespa
dc.subject.keywordIncubation timespa
dc.subject.keywordInternal mammary arteryspa
dc.subject.keywordMental concentrationspa
dc.subject.keywordPriority journalspa
dc.subject.keywordVasodilatationspa
dc.subject.keywordCaffeinespa
dc.subject.keywordDose-response relationshipeng
dc.subject.keywordGlyburidespa
dc.subject.keywordHumansspa
dc.subject.keywordMammary arteriesspa
dc.subject.keywordPotassium channel blockersspa
dc.subject.keywordPotassium channelsspa
dc.subject.keywordVasodilationspa
dc.subject.keywordCaffeinespa
dc.subject.keywordInternal mammary arteryspa
dc.subject.keywordPotassium channelspa
dc.subject.keywordVasodilationspa
dc.titleThe role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteriesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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