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Características y factores asociados a desenlaces clínicos en pacientes con falla hepática aguda sobre crónica entre 2018 al 2023

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dc.contributor.advisorVarón Puerta, Adriana
dc.contributor.advisorSanabria Jiménez, Angélica María
dc.creatorRojas Kozhakin, Daniel Valery
dc.creatorVaron Puerta, Adriana
dc.creatorSanabria Jiménez, Angélica María
dc.creator.degreeEspecialista en Hepatología
dc.creator.degreeLevelEspecialización
dc.date.accessioned2025-11-14T22:34:20Z
dc.date.available2025-11-14T22:34:20Z
dc.date.created2025-11-13
dc.descriptionLa cirrosis es una enfermedad crónica con un curso clínico variable que va desde el estadio compensado hasta la falla hepática aguda sobre crónica. El manejo de dichos pacientes se centra en el soporte multiorgánico en la unidad de cuidado intensivo (UCI). Sin embargo, no están claramente establecidos los criterios para definir la futilidad o los potenciales candidatos para trasplante en nuestro medio. El objetivo del presente estudio es describir las características sociodemográficas, clínicas y factores asociados a desenlaces clínicos de pacientes adultos con falla hepática aguda sobre crónica atendidos en Unidad de Cuidados Intensivos (UCI) entre 2018 y 2023. Se documentó una mayor tasa de mortalidad en relación a disfunción renal, necesidad de ventilación mecánica invasiva, severidad de la alteración de la síntesis hepática o la presencia de cualquier tipo de infección. Las infecciones respiratorias y urinarias fueron las más frecuentes. No se encontró asociación con la respuesta inflamatoria sistémica ni con la mortalidad. La proporción de pacientes aptos para trasplante fue baja. Se requieren estudios prospectivos para identificar la población de pacientes que podría beneficiarse de un trasplante temprano y, por lo tanto, mejorar su supervivencia.
dc.description.abstractCirrhosis is a chronic disease with a variable clinical course, ranging from a compensated stage to acute-on-chronic liver failure. Management of these patients focuses on multi-organ support in the intensive care unit (ICU). However, criteria for defining futility or potential transplant candidates are not clearly established in our setting. The objective of this study is to describe the sociodemographic and clinical characteristics, as well as factors associated with clinical outcomes, of adult patients with acute-on-chronic liver failure treated in the Intensive Care Unit (ICU) between 2018 and 2023. A higher mortality rate was documented in relation to renal dysfunction, the need for invasive mechanical ventilation, the severity of impaired hepatic synthesis, or the presence of any type of infection. Respiratory and urinary tract infections were the most frequent. No association was found with systemic inflammatory response or mortality. The proportion of patients eligible for transplantation was low. Prospective studies are needed to identify the patient population that could benefit from early transplantation and thus improve their survival.
dc.format.extent30 pp
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_46934
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46934
dc.language.isospa
dc.publisherUniversidad del Rosario
dc.publisher.departmentEscuela de Medicina y Ciencias de la Salud
dc.publisher.programEspecialización en Hepatología
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
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dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectCirrosis hepática
dc.subjectFalla hepática aguda sobre crónica
dc.subjectTrasplante hepático
dc.subjectUnidad de Cuidado Intensivo
dc.subject.keywordLiver cirrhosis
dc.subject.keywordAcute-on-chronic liver failure
dc.subject.keywordLiver transplantation
dc.subject.keywordIntensive Care Unit
dc.titleCaracterísticas y factores asociados a desenlaces clínicos en pacientes con falla hepática aguda sobre crónica entre 2018 al 2023
dc.title.TranslatedTitleCharacteristics and Factors Associated with Clinical Outcomes in Patients with Acute-on-Chronic Liver Failure between 2018 to 2023
dc.title.alternativeCaracteristicas de pacientes con Falla Hepática Aguda Sobre Crónica
dc.typemasterThesis
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de grado
local.department.reportEscuela de Medicina y Ciencias de la Salud
local.regionesBogotá
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