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Cytogenetic study in peripheral blood of melanoma patients

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dc.creatorRondón-Lagos S.spa
dc.creatorRangel N.spa
dc.creatorRamírez Clavijo, Sandra Rocíospa
dc.date.accessioned2020-05-25T23:55:43Z
dc.date.available2020-05-25T23:55:43Z
dc.date.created2009spa
dc.description.abstractAmong all the skin diseases, melanoma is the main cause of death in Colombia (40 %) and it represents 1 % of all deaths by cancer. Due to the fast increase in the incidence of melanoma, it is necessary to carry out research on the mechanisms involved in its genesis and progression. This study determined chromosomal anomalies from peripheral blood samples on 30 patients with melanoma and on 23 control subjects using conventional cytogenetics (G Banded), where a high incidence in numerical anomalies and a low incidence in recurrent structural rearrangements were observed. Chromosomic losses were prevalent in all the tumor stages studied. The analysis showed that the chromosomes X, 9 and 17 were mainly affected. Among the numerical anomalies, monosomies in X and 17 chromosomes, as well as trisomies formed by a marker chromosome, were the most common in both early and late stages of the disease. Deletions and chromosomal crossovers appeared to be as isolated anomalies. In the control group no anomaly was identified, and a low percentage of fragility was observed when compared with the patients group. A high frequency in chromosomal anomalies was observed in patients, in contrast with the control subjects. This suggests the existence of heterogeneity and genetic predisposition during the illness development. To further research, these must be analyzed and validated as possible sources of molecular markers, which could be of use for the early diagnosis, treatment and follow up of the disease.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn5355133
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22186
dc.language.isoengspa
dc.relation.citationEndPage186
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage173
dc.relation.citationTitleInvestigacion Clinica
dc.relation.citationVolumeVol. 50
dc.relation.ispartofInvestigacion Clinica, ISSN:5355133, Vol.50, No.2 (2009); pp. 173-186spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-70349562561&partnerID=40&md5=0ade89557b3f8ed055922b60f587291fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordBlood samplingspa
dc.subject.keywordCancer stagingspa
dc.subject.keywordChromosome 17spa
dc.subject.keywordChromosome 9spa
dc.subject.keywordChromosome aberrationspa
dc.subject.keywordClinical articlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordCrossing overspa
dc.subject.keywordCytogeneticsspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordHumanspa
dc.subject.keywordMelanomaspa
dc.subject.keywordMonosomyspa
dc.subject.keywordTrisomyspa
dc.subject.keywordX chromosomespa
dc.subject.keywordAneuploidyspa
dc.subject.keywordBloodspa
dc.subject.keywordChromosome aberrationspa
dc.subject.keywordChromosome banding patternspa
dc.subject.keywordChromosome fragile sitespa
dc.subject.keywordFemalespa
dc.subject.keywordGeneticsspa
dc.subject.keywordKaryotypingspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordSkin tumorspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAged, 80 and overspa
dc.subject.keywordAneuploidyspa
dc.subject.keywordChromosome aberrationsspa
dc.subject.keywordChromosome bandingspa
dc.subject.keywordChromosome fragile sitesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordKaryotypingspa
dc.subject.keywordMalespa
dc.subject.keywordMelanomaspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordSkin neoplasmsspa
dc.subject.keywordYoung adultspa
dc.subject.keywordChromosomal anomaliesspa
dc.subject.keywordCytogeneticspa
dc.subject.keywordMelanomaspa
dc.titleCytogenetic study in peripheral blood of melanoma patientsspa
dc.title.TranslatedTitleEstudio citogenético en sangre periférica de pacientes con melanomaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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